Predicting the Metabolic Biomarkers Associated With Injury in Athletes

For elite athletes, sports injuries significantly impede the further enhancement of their competitive performance. Consequently, the significance of preventing, detecting, and addressing potential injury issues has become increasingly critical. Currently, the comprehensive evaluation of athletes' physical function and condition primarily depends on a range of physiological, biochemical, and immunological indicators. However, these methods have progressively exposed their limitations. As an advanced bioinformatics technology, omics research demonstrates unique advantages. By leveraging multi-omics research and analysis, it is possible to more accurately observe the physiological and biochemical changes that athletes undergo during training and competition, as well as their regulatory mechanisms. This approach can provide practical data, identify biomarkers that can warn of potential injuries, and offer precise guidance for training monitoring and injury prevention. It also provides a foundation for developing diverse, precise, and personalized sports programs and rehabilitation plans.

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Key information

Conditions

Sports Medicine Wounds and Injuries

Age range

12 year–30 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Respiratory, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,China

Shanghai, 200092, China

About this study

Investigators will collect fasting venous blood. White blood cell count, red blood cell count, erythrocyte specific volume, hemoglobin, C-reactive protein, procalcitonin, erythrocyte sediment rate, lactic acid,creatine kinase, liver function indicators, blood urea, blood creatinine, blood uric acid, blood testosterone, blood cortisol, immunoglobulin (IgG, IgA, IgM) and ferritin levels were measured. The levels of IL-2, IL-6, IL-1β and TNF-α were determined by ELISA. Blood samples were purified and analyzed by proteomics, metabolomics and lipidomics methods. Urine and stool samples were collected and analyzed by multi-omics method.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age： Athletes 12-30 years old
Acute injury during exercise: such as muscle, sprain, contusion, torn ligament, dislocation, fracture.

Exclusion criteria

Athletes with serious cardio-cerebrovascular disease and abnormal liver and kidney function
Recent use of drugs or supplements that affect metabolism.
Pregnancy, lactation or special conditions that may affect metabolism.

Treatment and study plan

Primary outcomes

Number of participants with athletes with acute injuries

Time frame: 1year

Acute injuries are defined as the injuries of body tissues in a short period of time due to sudden external force or improper operation during sports.This injury usually has sudden and distinct traumatic features

Sponsors and collaborators

Lead sponsor

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Other

Registry information

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2027
First posted: Mar 21, 2025
Registry last updated: Apr 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed