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OpenTrials
Completed

NCT Number: NCT02834325

Predicting Success of HFNC: The Utility of the ROX Index

The purpose of the study was to describe early predictors and to develop a prediction tool that accurately identifies the need for mechanical ventilation in pneumonia patients with acute respiratory failure treated with High Flow nasal cannula.

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Key information

Conditions

Acute Respiratory Failure Infections Lung Diseases Pneumonia Respiratory Tract Diseases Respiratory Tract Infections

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Purpose The purpose of the study is to describe early predictors and to develop a prediction tool that accurately identifies the need for mechanical ventilation (MV) in pneumonia patients with hypoxemic acute respiratory failure (ARF) treated with high-flow nasal cannula (HFNC).

Materials and methods This is a 4-year prospective observational 2-center cohort study including patients with severe pneumonia treated with HFNC. High-flow nasal cannula failure was defined as need for MV. ROX index was defined as the ratio of pulse oximetry/fraction of inspired oxygen to respiratory rate.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosis of acute respiratory failure secondary to pneumonia receiving HFNC therapy

Exclusion criteria

  • younger than 18 years old
  • indication for mechanical ventilation at ICU admission
  • limitation of therapeutic effort

Treatment and study plan

mechanical ventilation

Procedure

Primary outcomes

  1. prediction of need for mechanical ventilation using ROX index

    Time frame: through study completion, an average of 1 year

    participants will be followed during their stay in the ICU registering the days with HFNC treatment and their need or not for mechanical ventilation.

Sponsors and collaborators

Lead sponsor

Hospital Universitari Vall d'Hebron Research Institute

Other

Registry information

Official study title

Predicting Failure of High Flow Nasal Cannula in Pneumonia Patients With Hypoxemic Respiratory Failure: The Utility of ROX Index

Important dates

Study start
2009
Primary completion
2012
Study completion
2012
First posted
Jul 15, 2016
Registry last updated
Jul 15, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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