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Completed

NCT Number: NCT04372225

Predicting Risk Factors of Postoperative Hypocalcemia After Total Thyroidectomy

With increasing economic pressures to shorten the length of hospital stay, there has been much recent interest in studying risk factors for the development of postoperative hypocalcemia.

The aim of this study was to investigate in patients undergoing total thyroidectomy whether serum calcium and/or PTH levels can predict hypoparathyroidism.

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Key information

Conditions

Hypoparathyroidism Calcium Metabolism Disorders Endocrine System Diseases Hypocalcemia Metabolic Diseases Nutritional and Metabolic Diseases Parathyroid Diseases Water-Electrolyte Imbalance

Sex eligibility

All sexes

Study type

Observational

Primary location

Conception Hospital

Marseille, 13005, France

About this study

Our study consists of analyzing the calcium (mmol/l) and PTH (pmol/l) levels on the first postoperative day. Postoperative treatment with calcium and vitamin D and the length of hospital stay is also taken into consideration.

We also analyze post-operative complications.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Total thyroidectomy

Exclusion criteria

  • concomitant parathyroidectomy for primary hyperparathyroidism
  • lobectomy only
  • completion thyroidectomy
  • central and lateral neck dissection
  • patients with calcium and/or vitamin D supplementation prior surgery
  • patients with known and significant osteoporosis and renal failure

Treatment and study plan

analysis of hypocalcemia

Other

analysis of postoperative calcium and PTH levels

Primary outcomes

  1. calcium and PTH thresholds

    Time frame: one years

    For all 477 patients postoperative calcium and PTH levels and treatment with calcium and vitamin D will be analyzed.

    Objective is to identify the calcium and PTH thresholds at which the patient after total thyroidectomy can be discharged without risk of hypocalcemia.

Sponsors and collaborators

Lead sponsor

Aix Marseille Université

Other

Registry information

Official study title

Predicting Risk Factors of Postoperative Hypocalcemia After Total Thyroidectomy: is Safe Discharge Without Supplementation Possible?

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
May 1, 2020
Registry last updated
May 1, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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