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Completed

NCT Number: NCT02178865

Predicting Normal vs. Carrier Status in Euploid Embryos of Translocation Carriers

The purpose of this study is to assess the accuracy of predicting the normal or carrier status of human embryos resulting from in vitro-fertilization (IVF) from patients carrying a balanced translocation.

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Key information

Conditions

Balanced Chromosomal Translocation

Age range

7 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Reproductive Medicine Associates of New Jersey

Basking Ridge, New Jersey, 07920, United States

About this study

This study aims to evaluate the validity of using informative SNPs to distinguish balanced from normal embryos. This will involve acquiring material from families to set phase for informative SNPs, evaluation of existing and new embryo SNP array data, and follow up analysis of children born after applying the procedure.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with balanced translocations who have undergone IVF

Exclusion criteria

  • those who do not wish to know their child(s) karyotype

Treatment and study plan

Primary outcomes

  1. Proportion of correct predictions of normal vs. balanced ploidy status as compared to conventional karyotype

    Time frame: up to 12 months once pregnant

Sponsors and collaborators

Lead sponsor

Reproductive Medicine Associates of New Jersey

Other

Registry information

Official study title

Evaluation of the Accuracy of Predicting Normal or Carrier Status in Euploid Embryos Produced by Patients With Balanced Translocations

Important dates

Study start
2014
Primary completion
2015
Study completion
2017
First posted
Jul 1, 2014
Registry last updated
Mar 17, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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