Predicting Factors of Post-Total Thyroidectomy Hypocaӏcemia

Predicting post-total thyroidectomy hypocalcemia involves a combination of patient-specific, disease-related, and surgical factors. Key predictive factors include the intrinsic characteristics of the thyroid disease, pre-operative levels of calcium and vitamin D, the degree of parathyroid gland manipulation or injury, advanced age, and pre-existing hyperthyroidism. While no single factor is definitive, a low post-operative parathyroid hormone (iPTH) level is a strong indicator of developing hypocalcemia

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Key information

Conditions

Hypocalcemia After Total Thyroidectomy Calcium Metabolism Disorders Hypocalcemia Metabolic Diseases Nutritional and Metabolic Diseases Water-Electrolyte Imbalance

Age range

21 year–76 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Mustaqbal University

Sfax, Safx, 54001, Tunisia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients requiring total thyroidectomy.
age between 18-75 years old
both gender
no co-existing disease.

Exclusion criteria

previous hemithyroidectomy, lobectomy, resection of the parathyroid gland. 2. 2. patients with missing laboratory data, previous subtotal thyroidectomy.

diagnosed pathology of the parathyroid gland

Treatment and study plan

Total thyroidectomy

Procedure

both lobes removed and observe the calcemic level

Primary outcomes

hypocalcemia incidence

Time frame: 1 day and 2 weeks after surgery
hypocalcemia other factors related to clinical status.

Time frame: 1 day and 2 weeks after surgery

Comparison of Serum Calcium levels of the studied group reported Comparison of PTH levels between hypocaӏcemia and Eucalcemic

Sponsors and collaborators

Lead sponsor

Al Safwa University College

Other

Registry information

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Oct 8, 2025
Registry last updated: Oct 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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