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NCT Number: NCT06681844

Predict Tooth Wear

Tooth wear, resulting from gradual loss of dental hard tissue due to mechanical and chemical factors, impacts tooth structure, texture, and function. It affects quality of life, with varying prevalence (26.9% to 90.0%), and is traditionally detected visually during check-ups, often at advanced stages. Monitoring alterations in tooth shape via intraoral scanners aids early detection, but restoration remains challenging. Prevention through early detection is vital, as patients may not fully comprehend tooth structure loss until visible. Recently, statistical shape analysis (SSA) used to learn the tooth anatomy and define a reference shape (biogeneric tooth) using. However, assuring landmark consistency is challenging mostly due to biases of the operator. Recently, a robust method called MEG-IsoQuad offered automated, isotopological remeshing. Combining this with SSA holds promise for diagnostic and simulation purposes. This study aims to assess the reliability of a remeshing-SSA approach for altered and intact premolar analysis and compare machine learning algorithms for simulating the shape of the initially intact tooth or future altered one.

The clinical perspective of the current work offers possibilities to:

* Prevent future tooth wear by detecting it at an early stage; and communicate better to the patient by presenting him/her potential future altered teeth * Simulate the adapted reconstruction for the altered tooth by simulating the initially intact one

Recruiting

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Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

KU Leuven University Hospital, Leuven, Belgium

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • teeth avulsed presenting a tooth wear index between 0 and 3
  • mature incisor, canine, premolar or molars (1st and 2nd only)

Exclusion criteria

  • teeth avulsed presenting a tooth wear index over 3 (or presenting an oral rehabilitation representative of a similar wear)
  • immature teeth or teeth without root edification
  • wisdom teeth

Treatment and study plan

Tooth Shape assessed using an intraoral scanner one after avulsion

Other
  • Tooth Shape assessed using an intraoral scanner one after avulsion and stored as StereoLithography (STL) file
  • Age, gender, reason of avulsion, type of tooth taken from the database and stored in a google sheet

Primary outcomes

  1. Prediction of the tooth wear index based on a dataset of dental shapes:a retrospective study

    Time frame: only once

    Four machine learning (ML) algorithms: a linear discriminant analysis (LDA) a support vector machine (SVM), a random forest (RM) and a gradient boosting machine (GBM) will be used to predict the tooth type and the alteration of the anatomy. The data set will be split into a 60/40 train and holdout test data set and models will be three-fold cross validated. Model performances will be evaluated in confusion matrices leading to define precision, recall, F1 score and accuracy.

Study contacts

Contact information is provided by the study sponsor or research team.

Maxime Ducret, Professor

CONTACT

[email protected]

Raphael Richet, Clinical Assistant

CONTACT

[email protected]

+33669523314

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Prediction of the Tooth Wear Index Based on a Dataset of Dental Shapes:a Retrospective Study

Acronym: PREDITOOTH

Important dates

Study start
2023
Primary completion
2025
Study completion
2027
First posted
Nov 8, 2024
Registry last updated
Nov 8, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.