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Completed

NCT Number: NCT03282032

Preconditioning of One-lung Ventilation

To observe the effect of one-lung ventilation (OLV) preconditioning on perioperative oxygenation during thoracic surgery.

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Key information

Conditions

One Lung Ventilation

Age range

20 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University Hospital

Seoul, 03080, South Korea

About this study

For lung isolation and better surgical view, one-lung ventilation(OLV) is essential for thoracic surgery. However, OLV may cause serious pulmonary complications due to intraoperative hypoxia.

Animal studies showed a positive effect of OLV preconditioning (Intermittent OLV before surgical intervention) on perioperative pulmonary oxygenation.

Thus, we designed a study to observe the effect of OLV preconditioning on perioperative oxygenation during thoracic surgery

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Elective thoracic surgery which requires one-lung ventilation with lateral decubitus position

Exclusion criteria

  • Patients with severe cardiopulmonary disease, COPD, previous surgical history of pulmonary disease
  • Thoracic surgery for pneumonectomy

Treatment and study plan

One-lung ventilation

Other

The patient undergoing thoracic surgery is intubated with double lumen tube after induction of general anesthesia with propofol and remifentanil.

In the intervention group, 5 cycles of one-lung ventilation preconditioning (2-min of one-lung ventilation and 2-min of two-lung ventilation for 1 cycle) is performed before surgical incision. One-lung ventilation is done at dependent lung with FiO2 100% and tidal volume 6 ml kg-1. Two-lung ventilation is done with FiO2 50%, tidal volume 8 ml kg-1.

Other names: Preconditioning

Primary outcomes

  1. Incidence of hypoxemia

    Time frame: during one-lung ventilation, up to 5 hours

    SpO2 < 95%

  2. P/F ratio

    Time frame: 30min after surgical incision

    PaO2/FIO2 ratio

Secondary outcomes

  1. Pulmonary complications

    Time frame: 6, 24, 48 hours after surgery, during hospital stay.

    Acute lung injury, acute respiratory distress syndrome, atelectasis, pneumonia

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Official study title

Preconditioning of One-lung Ventilation for Lung Protection

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Sep 13, 2017
Registry last updated
Nov 30, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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