Precision Imaging to Evaluate Kaposi Sarcoma

Primary outcomes

1. Reproducibility of KS lesion size measurements between SkinScan3D and current standard of care measurement - Aim 2 Only

   Time frame: Approximately 3 months

   Reproducibility/agreement between clinicians for each method is measured using the concordance correlation coefficient (CCC). A higher CCC means a more reproducible method.

2. Accuracy of KS lesion size measurements between SkinScan3D and current standard of care measurement - Aim 2 Only

   Time frame: Approximately 3 months

   Accuracy is measured using the coefficient of determination (R-squared). The R-squared tells us how much variation is due to varying lesion size as measured by either method versus how much variation is due to random error. When the variation due to random error is small, the R-squared value is closer to 1; when the variation due to random error is large, the R-squared value is farther from 1.

3. Device usability - Aim 3 Only

   Time frame: 6 months

   Device usability will be measured using the System Usability Scale. The SUS will result in a single composite score for each individual and the scores will be averaged to result in a single overall usability score.

4. Acceptability - Aim 3 Only

   Time frame: 6 months

   Acceptability of Intervention Measure (AIM), present participants with a set of 4 questions regarding their perception of an intervention's acceptability, typically on a 5-point Likert scale (completely disagree to completely agree), then calculate the average score across all items, with higher scores indicating greater perceived acceptability of the intervention.

5. Appropriateness - Aim 3 Only

   Time frame: 6 months

   Intervention Appropriateness Measure (IAM), will present a set of four questions to healthcare providers about how well SS3D works in their context. Each item is rated on a Likert scale, with higher scores indicating greater perceived appropriateness.

6. Feasibility - Aim 3 Only

   Time frame: 6 months

   FIM (Feasibility of Intervention Measure), will give the four-item questionnaire to healthcare providers asking them to rate how feasible they believe a specific intervention is on a Likert scale, usually ranging from "completely disagree" to "completely agree"; a higher score indicates greater perceived feasibility, with the average score across all items representing the overall feasibility rating of the intervention in that context.