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NCT Number: NCT07533747

PRECISE Phenotyping to Guide Therapies for Coronary Microvascular Dysfunction

Some people experience chest pain and shortness of breath, but when they have tests, no blockages are found in their main heart arteries. The most common cause of symptoms is related to abnormalities in the small blood vessels, also known as 'small vessel angina' or Coronary Microvascular Dysfunction (CMD). Currently, the diagnosis of CMD requires additional measurements of blood flow in the heart vessel during a minimally invasive procedure known as a coronary angiogram.

CMD affects many people and can lead to repeated hospital visits and a lower quality of life, and diagnosing the condition leads to better patient outcomes. However, there are still no widely available, proven treatments for this condition and therefore several patients remain symptomatic.

This study aims to find better ways to treat CMD, especially by understanding how the heart uses energy and how this might relate to symptoms.

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Key information

Conditions

Coronary Microvascular Dysfunction (CMD)

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Angina with non-obstructive coronary arteries

Exclusion criteria

  • Significant epicardial coronary stenoses
  • Inability to carry out bike exercise
  • Contra-indication to adenosine administration
  • Insulin usage with frequent hypoglycaemic episodes

Treatment and study plan

Empagliflozin 10mg OD

Drug

Drug

Primary outcomes

  1. Myocardial Perfusion Reserve

    Time frame: 8 weeks

    Perfusion Cardiac Magnetic Resonance Imaging

Study contacts

Contact information is provided by the study sponsor or research team.

Haseeb Rahman, MA BMBCh MRCP PhD

CONTACT

[email protected]

United Kingdom

Sponsors and collaborators

Lead sponsor

King's College London

Other

Collaborators

  • Guy's and St Thomas' NHS Foundation Trust

Registry information

Acronym: PRECISE-CMD

Important dates

Study start
2026
Primary completion
2031
Study completion
2031
First posted
Apr 16, 2026
Registry last updated
Apr 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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