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Completed

NCT Number: NCT04539054

Pre-workout Supplement Versus Caffeine on Energy Expenditure.

The primary purpose of this study was to examine the acute effects of a multi-ingredient pre-workout supplement versus an ergogenic dose of caffeine (6 mg/kg) on energy expenditure during low-intensity exercise. The effects of these substances on substrate utilization, gas exchange, and psychological factors were also investigated. Twelve males (mean ± SD: age = 22.8 ± 2.4 years) completed three bouts of 60-min of treadmill exercise at 4.8-6.4 km/hr on separate days after consuming a pre-workout supplement, 6 mg/kg of caffeine, or placebo in a randomized fashion. The pre-workout and caffeine supplements resulted in significantly greater energy expenditure (p < 0.001, p = 0.006, respectively), VO2 (p < 0.001, p = 0.007, respectively), VCO2 (p = 0.006, p = 0.049, respectively), and VE (p < 0.001, p = 0.007, respectively), but not rates of fat or carbohydrate oxidation or respiratory exchange ratio compared to placebo (collapsed across condition). In addition, the pre-workout supplement increased feelings of alertness (p = 0.015) and focus (p = 0.005) 30-minutes post-ingestion and decreased feelings of fatigue (p = 0.014) during exercise compared to placebo (collapsed across condition). Thus, the pre-workout supplement increased energy expenditure and measures of gas exchange to the same extent as 6 mg/kg of caffeine with concomitant increased feelings of alertness and focus and decreased feelings of fatigue.

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Key information

Conditions

Healthy

Age range

19 year–29 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Exercise Physiology Laboratory

DeKalb, Illinois, 60115, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male

Exclusion criteria

  • history of medical or surgical events, including cardiovascular disease, metabolic, renal, hepatic, or musculoskeletal disorders;
  • use of any medications
  • use of nutritional supplements
  • habitual use of caffeine (≥1 caffeinated beverage per day)
  • participation in another clinical trial or investigation of another investigational product within 30 days prior to screening/enrollment.

Treatment and study plan

ENGN Shred

Dietary Supplement

ENGN Shred is a multi-ingredient pre-workout supplement.

Nutricost caffeine powder

Dietary Supplement

Caffeine powder.

Crystal Light

Dietary Supplement

Non-caloric Crystal Light matched for the pre-workout in terms of flavor and consistency.

Primary outcomes

  1. Energy expenditure

    Time frame: Measured continuously during 60 minutes of exercise for all three supplement conditions

    Measurement of caloric expenditure via gas exchange

Secondary outcomes

  1. Oxygen consumption

    Time frame: Measured continuously during 60 minutes of exercise for all three supplement conditions

    Measurement of rate of oxygen consumption using a metabolic cart

  2. Carbon dioxide production

    Time frame: Measured continuously during 60 minutes of exercise for all three supplement conditions

    Measurement of rate of carbon dioxide production using a metabolic cart

  3. Minute ventilation

    Time frame: Measured continuously during 60 minutes of exercise for all three supplement conditions

    Measurement of ventilation rate using a metabolic cart

  4. Feelings of fatigue

    Time frame: Baseline, 30-minutes post-ingestion of supplement, and at the 30-minute time point of exercise for all three supplement conditions

    Subjects were asked to rate their feelings of fatigue using a 5-point Likert scale

  5. Feelings of energy

    Time frame: Baseline, 30-minutes post-ingestion of supplement, and at the 30-minute time point of exercise for all three supplement conditions

    Subjects were asked to rate their feelings of energy using a 5-point Likert scale

  6. Feelings of focus

    Time frame: Baseline, 30-minutes post-ingestion of supplement, and at the 30-minute time point of exercise for all three supplement conditions

    Subjects were asked to rate their feelings of focus using a 5-point Likert scale

  7. Feelings of alertness

    Time frame: Baseline, 30-minutes post-ingestion of supplement, and at the 30-minute time point of exercise for all three supplement conditions

    Subjects were asked to rate their feelings of focus using a 5-point Likert scale

  8. Rate of fat oxidation

    Time frame: Measured continuously during 60 minutes of exercise for all three supplement conditions

    Fat oxidation was estimated thru measurements of gas exchange

  9. Rate of carbohydrate oxidation

    Time frame: Measured continuously during 60 minutes of exercise for all three supplement conditions

    Carbohydrate oxidation was estimated thru measurements of gas exchange

Sponsors and collaborators

Lead sponsor

Northern Illinois University

Other

Registry information

Official study title

Effects of a Multi-ingredient Pre-workout Supplement Versus Caffeine on Energy Expenditure and Feelings of Fatigue During Low-intensity Treadmill Exercise in College-aged Males.

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Sep 4, 2020
Registry last updated
Sep 4, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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