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NCT Number: NCT00650962

Pre-shock Cardiopulmonary Resuscitation to Patients With Out-of-hospital Resuscitation, A Randomised Clinical Trial

1. Pre-shock cardiopulmonary resuscitation might benefit the survival of out-of-hospital cardiac patients with ventricular fibrillation / ventricular tachycardia in a post-hoc analysis of a prehospital trial conducted in Europe (L.Wik,2002). However, it's effectiveness in the Asian countries, where most firstly recorded rhythm in out-of-hospital cardiac arrests patients were asystole/pulseless electric activity rather than ventricular fibrillation / ventricular tachycardia, were not explored yet. 2. This trial was designed to exam if pre-shock cardiopulmonary resuscitation by emergency medical technicians improves the outcome of all out-of-hospital cardiac arrest patients in an Asian metropolitan city.

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Key information

Conditions

Cardiac Arrest Cardiovascular Diseases Heart Arrest Heart Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Emergency Medicine, National Taiwan University Hospital

Taipei, Taiwan

About this study

  • Different from data from the Western countries, non-shockable rhythm (Asystole/pulseless electric activity) was responsible for most out-of-hospital cardiac arrest patients(80%~90%) in metropolitan Taipei.
  • Response time in Taipei emergency medical service was longer than 5 minutes.
  • Bystander cardiopulmonary resuscitation rate were relatively low in Taipei.
  • Cardiopulmonary resuscitation is the only known method to save out-of-hospital cardiac arrest patients with asystole/pulseless electric activity. For those suffered from ventricular fibrillation/ ventricular tachycardia,previous studies revealed pre-shock cardiopulmonary resuscitation may have the potential to improve the outcome.
  • Study hypothesis: Compared with current standard resuscitative sequence (basic life support protocol in Guideline 2005), longer pre-shock cardiopulmonary resuscitation provided to all out-of-hospital cardiac arrest patients in Taipei may improve the outcome of them.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with out-of-hospital cardiac arrest

Exclusion criteria

  • Trauma
  • Age < 18y/o
  • Airway obstruction
  • Submersion
  • Sign of obvious death
  • existing do not resuscitate (DNAR) order
  • family refusal
  • preceding CPR by BLS teams for longer than 2 minutes.

Treatment and study plan

cardiopulmonary resuscitation

Other

10 cycles of 30:2 cardiopulmonary resuscitation before rhythm analysis by AED

Other names: automatic external defibrillator

Rhythm analysis

Other

Rhythm analysis as soon as AED is ready

Other names: cardiopulmonary resuscitation, automatic external defibrillator

Primary outcomes

  1. Sustained ROSC >= 2 hours

    Time frame: 180 days

Secondary outcomes

  1. surival to ICU admission

    Time frame: 180 days

  2. survival to hospital discharge

    Time frame: 180 days

  3. Rates of good neurology recovery (CPC 1 &2)

    Time frame: 180 days

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Collaborators

  • National Science and Technology Council, Taiwan

Registry information

Official study title

Does Longer Pre-shock Cardiopulmonary Resuscitation Improve the Outcome of Patients With Out-of-hospital Cardiac Arrest? A Randomized Control Trial.

Acronym: CPR

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Apr 2, 2008
Registry last updated
Jan 5, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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