Pre-operative 5% Dextrose Infusion & PONV

With this study, we aim to compare the efficacy of pre-operative dextrose-containing fluid infusion with other fluid for the prevention of PONV in middle ear surgeries.

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Key information

Conditions

Nausea, Postoperative Nausea Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Nausea and Vomiting Signs and Symptoms Signs and Symptoms, Digestive Vomiting

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Medicine- Cairo University

Cairo, 11562, Egypt

About this study

We hypothesized that maintenance of stable level of blood glucose in addition to adequate hydration through preoperative intravenous dextrose 5% infusion will have a rule in decreasing the incidence and severity of PONV; as it reduces insulin resistance and decreases gastric acid secretion; which may contribute to PONV.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

ASA physical status I and ll.
Patients undergoing middle ear surgeries, mastoidectomy, or tympanoplasty

Exclusion criteria

history of dependence or use of antiemetics
history of motion sickness
presence of psychiatric illness
pregnant and lactating women
cardiovascular disorders (Ischemic heart diseases, congestive heart failure and valvular diseases)
Diabetic patients

Treatment and study plan

Dextrose 5%, normal saline

Dietary Supplement

Decrease fasting hours

Primary outcomes

PONV

Time frame: 24 hours

incidence

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Is Pre-operative Infusion of 5% Dextrose Effective in Reducing the Incidence of PONV in Middle Ear Surgery? A Blinded Randomized Control Trial

Important dates

Study start: 2023
Primary completion: 2024
Study completion: 2024
First posted: Jul 17, 2023
Registry last updated: Mar 27, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed