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NCT Number: NCT07415603

PPV vs PVI in the Supine and Prone Position

This is a prospective study that will record the Pulse Pressure Variability (PPV) from the arterial line and Plethysmography Variability Index (PVI) from the pulse oximeter while the patient is in the supine position and then again in the prone position. There will be no change in anesthetic care based on the study protocol.

The primary objective of this study is to evaluate the changes in PVI and PPV when changing from the supine and prone position in pediatric-aged patients.

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Key information

Conditions

Surgeries Undergoing General Anesthesia

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Consenting ASA 1-4 patients
  • Undergoing a surgical procedure with general anesthesia that requires placement of an arterial cannula and prone positioning

Exclusion criteria

  • Patients in whom an arterial cannula is not indicated or cannot be placed
  • Patients undergoing a surgical procedure that does not require prone positioning

Treatment and study plan

observation

Other

No intervention

Primary outcomes

  1. PPV Supine

    Time frame: Once a minute for 5 minutes

    Pulse Pressure Variability (PPV) recorded from the arterial line while supine.

  2. PVI Supine

    Time frame: Once a minute for 5 minutes

    Plethysmography Variability Index (PVI) recorded from the pulse oximeter while supine.

  3. PPV Prone

    Time frame: Once a minute for 5 minutes

    Pulse Pressure Variability (PPV) recorded from the arterial line while prone.

  4. PVI Prone

    Time frame: Once a minute for 5 minutes

    Plethysmography Variability Index (PVI) recorded from the pulse oximeter while prone.

Study contacts

Contact information is provided by the study sponsor or research team.

Catherine Roth, MPH

CONTACT

[email protected]

Julie Rice-Weimer, BSN

CONTACT

[email protected]

614-355-3142

Sponsors and collaborators

Lead sponsor

Joseph D. Tobias

Other

Registry information

Official study title

Variability and Correlation of the Pulse Pressure Variability (PPV) and the Plethysmography Variability Index (PVI) in the Supine and Prone Position

Important dates

Study start
2026
Primary completion
2029
Study completion
2029
First posted
Feb 17, 2026
Registry last updated
Feb 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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