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NCT Number: NCT03647072

PPI Versus Histamine Antagnists as Adjuvant to Chemotherapy

The study is a Comparative Clinical and Biochemical Study Evaluating the effect of Proton Pump I nhibitors versus histamine 2 Receptor antagonists as an adjuvant with chemotherapy in patients with Non-hodgkin Lymphoma.

Recruiting

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Key information

Conditions

Lymphoma Hemic and Lymphatic Diseases Immune System Diseases Immunoproliferative Disorders Lymphatic Diseases Lymphoproliferative Disorders Neoplasms Neoplasms by Histologic Type

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

About this study

The study is a Comparative Clinical and Biochemical Study Evaluating the effect of Proton Pump Inhibitors versus histamine 2 Receptor antagonists as an adjuvant with chemotherapy in patients with Non-hodgkin Lymphoma to compare the difference in efficacy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • DLBCL Lymphoma subtype --No comorbid disease

Exclusion criteria

  • Pregnancy
  • Peptic ulcer
  • Severe cardiac disease
  • Osteoporosis

Treatment and study plan

CHOP

Drug

CHOP only

Other names: CHOP protocol

CHOP Plus Lanzoprazole

Drug

CHOP plus Lanzoprazole 60 mg

Other names: CHOP Plus Lanzoprazole 60

CHOP Plus Famotidine

Drug

CHOP Plus Famotidine 40 mg

Other names: CHOP Plus Famotidine 40

Primary outcomes

  1. Number of patients eith radiological and clinical improvement

    Time frame: 6 months

    Number of patients eith radiological and clinical improvement after cycles of chemotherapy

Study contacts

Contact information is provided by the study sponsor or research team.

Sherief Abd-Elsalam, MD

CONTACT

[email protected]

00201147773440

Sponsors and collaborators

Lead sponsor

Sherief Abd-Elsalam

Other

Registry information

Official study title

Comparative Clinical and Biochemical Study Evaluating the Effect of Proton Pump I Nhibitors Versus Histamine 2 Receptor Antagonists as an Adjuvant With Chemotherapy in Patients With Non-hodgkin Lymphoma.

Important dates

Study start
2018
Primary completion
2027
Study completion
2027
First posted
Aug 27, 2018
Registry last updated
Aug 27, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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