Skip to main content
OpenTrials
Completed

NCT Number: NCT03680807

Power Production in Older Adults With Knee Osteoarthritis

Knee osteoarthritis is an important cause of functional disabilities at old age. Previous research has demonstrated that individuals with knee osteoarthritis have reduced knee-extensor strength in comparison to healthy individuals. However, rapid power production declines more than strength as a consequence of ageing and is more predictive of functional capacity. However, limited research has investigated whether individuals with knee osteoarthritis have reduced ability to develop strength and power rapidly on top of reduced maximal strength capacities, which is the primary aim of the current study.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Osteo Arthritis Knee Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

50 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Movement Sciences

Leuven, 3001, Belgium

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Group with knee osteoarthritis:

  • Diagnosed with knee osteoarthritis based on RX.

Exclusion criteria

Healthy group:

  • Systematic engagement in (resistance) exercise in the 12-months prior to participation
  • Cardiovascular disease
  • Neurological disorders
  • Cognitive malfunctioning
  • Severe knee or hip problems

Group with knee osteoarthritis:

  • Systematic engagement in (resistance) exercise in the 12-months prior to participation
  • Cardiovascular disease
  • Neurological disorders
  • Cognitive malfunctioning
  • Severe hip problems

Treatment and study plan

Muscle function test

Diagnostic Test

Power and strength tests of the knee-extensor muscles, handgrip strength, functional capacity tests

Primary outcomes

  1. Rate of power development

    Time frame: up to 3 months

    Subjects perform a test protocol on a Biodex dynamometer, consisting of isotonic contractions of the leg-extensor muscles. Subjects are instructed to kick as fast as possible against different (relative) loads. The rate of power development (watt/s) is defined as the linear slope of the power-time curve and is measured from the onset of movement till peak power.

Secondary outcomes

  1. Maximal isometric strength

    Time frame: up to 3 months

    Maximal strength (Nm) is measured by means of unilateral isometric knee-extensor tests on a Biodex dynamometer.

  2. Maximal isokinetic strength

    Time frame: up to 3 months

    Maximal strength (Nm) is measured by means of unilateral isokinetic knee-extensor tests on a Biodex dynamometer.

  3. Stair Climbing performance

    Time frame: up to 3 months

    Stair ascent duration (in s), the time needed to ascent a flight of stairs.

  4. Gait speed

    Time frame: up to 3 months

    The average speed to walk 10m as fast as possible (in m/s).

  5. 5 repetition sit-to-stand test

    Time frame: up to 3 months

    The time needed to perform 5 sit-to-stand transitions (in s).

  6. Timed-up-and-go

    Time frame: up to 3 months

    The time needed to stand up from a chair, walk 3m, turn, walk back and sit down.

  7. Handgrip strength

    Time frame: up to 3 months

    Handgrip strength (kg) evaluated with Jamar dynamometer.

Sponsors and collaborators

Lead sponsor

KU Leuven

Other

Registry information

Official study title

Power Production in Older Adults With Knee Osteoarthritis Compared to Healthy Counterparts

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Sep 21, 2018
Registry last updated
Feb 8, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.