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Recruiting

NCT Number: NCT06337227

Potential Role of Sirtuins As Epigenetic Biomarkers of the Patient with Atherosclerosis or Calcific Aortic Stenosis

The project aims to shed light on the role of Sirtuins, enzymes belonging to the third class of histone deacetylases (class III) involved in epigenetic modifications (deacetylation), focusing mainly on Sirtuin 6 (SIRT6), as a regulator of atherosclerosis and severe aortic valve stenosis through molecular-based and epigenetic studies in human VSMC cells.

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Key information

Conditions

Atherosclerosis and Calcific Aortic Stenosis with and Without Diabetes Arterial Occlusive Diseases Arteriosclerosis Atherosclerosis Cardiovascular Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with atherosclerosis or calcific aortic stenosis with and without diabetes older than 18 years of either sex;
  • Patients without atherosclerosis undergoing surgical procedure for endocarditis;
  • Patients who will have signed informed consent

Exclusion criteria

  • Patients for whom biological material cannot be recovered for study purposes;
  • Patients who refuse to participate in the study

Treatment and study plan

lncRNA signature analyses

Diagnostic Test

Specific validation experiments will be performed by Real-Time PCR (C-reactive protein), Western Blot, flow cytometry and microscopy

Primary outcomes

  1. To evaluate by analysis of data obtained from NGS techniques whether and which proteins belonging to the Sirtuin family may be deregulated in patients with atherosclerosis or calcific aortic stenosis

    Time frame: 36 months

Secondary outcomes

  1. To evaluate the experimental results achieved in the clinical-diagnostic context

    Time frame: 36 months

Sponsors and collaborators

Lead sponsor

IRCCS SYNLAB SDN

Other

Collaborators

  • Federico II University

Registry information

Official study title

Potential Role of Sirtuins As Epigenetic Biomarkers for the Clinical Management of the Patient with Atherosclerosis or Calcific Aortic Stenosis

Important dates

Study start
2023
Primary completion
2025
Study completion
2026
First posted
Mar 29, 2024
Registry last updated
Mar 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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