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Completed

NCT Number: NCT01150955

Potential Beneficial Effects of Resveratrol

We want to investigate whether the food supplement resveratrol is able to counteract the detrimental effects of obesity.

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Key information

Conditions

Metabolic Syndrome Body Weight Diabetes Mellitus Digestive System Diseases Endocrine System Diseases Fatty Liver Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Liver Diseases Metabolic Diseases Non-alcoholic Fatty Liver Disease Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Aarhus University Hospital, Department of Endocrinology, MEA

Aarhus, 8000, Denmark

About this study

The aim of this study is to investigate potential metabolic effects of resveratrol in healthy but obese men. We hypothesize that resveratrol will counteract some of the detrimental effects of obesity, and as an imitator of calorie restriction will give new insight into the basic biochemical pathways underpinning human metabolism. Of special interest is the potential connection between resveratrol, calorie restriction, SIRT1, STAT5b and the GH/IGF-I axis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI > 30 kg/m2
  • Otherwise healthy
  • Written informed consent

Exclusion criteria

  • Any disease
  • Alcohol dependency
  • Allergy to trial medication
  • Present or previous malignancy
  • Participation in other clinical trials within three months before randomization

Treatment and study plan

Resveratrol

Dietary Supplement

500 mg three times a day for five weeks.

Other names: Fluxome Sciences.

Placebo

Other

Placebo (starch capsules) 500 mg three times a day for five weeks.

Other names: Starch

Primary outcomes

  1. Metabolic parameters

    Time frame: Five weeks

    Regarding glucose, protein and fat metabolism.

Secondary outcomes

  1. Pathways of substrate metabolism.

    Time frame: Five weeks

    Description of the biochemical pathways underpinning the interplay between calorie restriction, SIRT1, STAT5 and the GH/IGF-I axis.

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Collaborators

  • The Ministry of Science, Technology and Innovation, Denmark

Registry information

Official study title

Potential Beneficial Effects of Resveratrol on Obesity, Metabolic Syndrome and Inflammation - Emphasis on Description of the Molecular Biology Underpinning the Interplay Between Calorie Restriction, SIRT1, STAT5 and the GH/IGF-I Axis

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Jun 25, 2010
Registry last updated
Mar 22, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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