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OpenTrials
Active, Not Recruiting

NCT Number: NCT05389995

Potassium Citrate and Crystal Light Lemonade

To define the effect of crystal light, potassium citrate, or both on urinary stone risk factors in patients with a history of stone and hypocitraturia/low pH

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Kidney Stone Calculi Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Calculi Kidney Diseases Male Urogenital Diseases Nephrolithiasis Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Urinary Calculi Urogenital Diseases Urolithiasis Urologic Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Northwestern University

Chicago, Illinois, 60611, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women between age 18-80 years
  • Willing to follow experimental protocol
  • Willing to complete 24-hour urine collections (three total)
  • Willing to sign the informed consent form
  • Completed Litholink Collection with blood work with results

a. hypocitraturia OR aciduria i. Hypocitraturics must meet definition of < 450 mg/day for men < 550 mg/day for women.

b. Low urine pH must be less than 5.6 c. potassium, BUN, creatinine, eGFR and hemoglobin A1c within normal limits

Exclusion criteria

  • Patients with severe hypocitraturia < 200 mg/day (men or women)
  • Patients with hyperkalemia, uncontrolled diabetes, chronic kidney disease, adrenal insufficiency, delayed gastric emptying (or drug induced delayed gastric emptying), peptic ulcer disease, or active UTI
  • Patients with distal renal tubular acidosis or medication induced RTA (e.g. carbonic anhydrase inhibitor, topiramate)
  • Members of vulnerable patient populations
  • Allergies to ingredients in crystal light
  • Patients lacking decisional capacity

Treatment and study plan

potassium citrate

Drug

7 days potassium citrate followed by 24 hour urine collection

Crystal light

Drug

7 days crystal light followed by 24 hour urine collection

Potassium citrate + crystal light

Drug

7 days potassium citrate + crystal light followed by 24 hour urine collection

Primary outcomes

  1. urine citrate levels

    Time frame: Day 7 of week 1

    24 hour urine collection

  2. urine citrate levels

    Time frame: Day 7 of week 3

    24 hour urine collection

  3. urine citrate levels

    Time frame: Day 7 of week 5

    24 hour urine collection

Sponsors and collaborators

Lead sponsor

Northwestern University

Other

Registry information

Official study title

Assessing the Effects of a Commercial Lemonade Beverage and Potassium Citrate on Urinary Stone Risk Factors

Important dates

Study start
2022
Primary completion
2025
Study completion
2027
First posted
May 25, 2022
Registry last updated
Jan 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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