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Completed

NCT Number: NCT02978066

Postspinal Hypotension and Cardiac Performance in the Elderly

Patients, scheduled for elective arthroplasty were monitored with Lithium Dilution Cardiac Output monitor (LiDCOplus™) before and 45 minutes after spinal anesthesia. Hypotension was defined as systolic blood pressure ≤ 100 mmHg or ≥ 30% decrease from baseline. Associations between hypotension and the hemodynamic changes after preanaesthetic fluid loading and spinal anesthesia were analysed by logistic regression analyses.

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Key information

Conditions

ARTHROPLASTY, REPLACEMENT; ANESTHESIA

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • hip or knee arthroplasty
  • spinal anaesthesia
  • age 65 years or more

Exclusion criteria

  • weight <40kg
  • concomitant lithium medication
  • written informed consent not obtained
  • research team unavailable

Treatment and study plan

Spinal anaesthesia

Other

Primary outcomes

  1. Stroke volume in ml

    Time frame: 0-45 minutes after spinal anaesthesia

    the blood volume pumped by the heart at each stroke

Secondary outcomes

  1. Arterial blood pressure mmHg and change from baseline

    Time frame: 0-45 minutes after spinal anaesthesia

    mmHg measured by arterial catheter

Sponsors and collaborators

Lead sponsor

Karolinska Institutet

Other

Registry information

Official study title

Is Postspinal Hypotension a Sign of Impaired Cardiac Performance in the Elderly? An Observational Mechanistic Study

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Nov 30, 2016
Registry last updated
Sep 18, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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