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Completed

NCT Number: NCT06657287

Postprandial Hypotension and Insulin Levels

The goal of this observational study is to learn about the relationship between postprandial hypotension and insulin levels in adults. The main question it aims to answer is:

Is the incidence of postprandial hypotension high in patients who undergo mixed meal test?

Is insulin level higher in individuals with postprandial hypotension compared to those without during a mixed meal test?

Patients with postprandial symptoms were scheduled for a mixed meal test, during which plasma glucose, insulin, C-peptide, blood pressure, and heart rate were measured at specific time points.

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Key information

Conditions

Postprandial Hypotension Cardiovascular Diseases Glucose Metabolism Disorders Hyperinsulinism Hypoglycemia Hypotension Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases Vascular Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ankara Bilkent City Hospital

Ankara, Çankaya, 06800, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults with postprandial symptoms

Exclusion criteria

  • Individuals with prediabetes or diabetes,
  • Those aged 65 and above,
  • Patients using antihypertensive medications or with known hypertension,
  • Those with active infections,
  • Congestive heart failure,
  • Peripheral artery disease,
  • Advanced-stage dementia,
  • Individuals who could not provide a history or were unable to cooperate,
  • Patients using medications that could induce hypoglycemia (oral antidiabetics, insulin, beta-blockers, hydroxychloroquine, bromocriptine, etc.)
  • Those with conditions that could cause hypoglycemia (uncontrolled hypothyroidism, adrenal insufficiency, growth hormone deficiency, etc.)

Treatment and study plan

Mixed meal test

Other

The biochemical parameters, blood pressure, and heart rates of participants undergoing the mixed meal test will be recorded over a 5-hour period.

Primary outcomes

  1. Systolic blood pressure

    Time frame: During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min)

    mmHg

  2. Blood glucose

    Time frame: During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min)

    mg/dL

  3. Blood insulin

    Time frame: During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min)

    uIU/mL

Secondary outcomes

  1. Blood C-peptide

    Time frame: During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min)

    ng/mL

  2. Diastolic blood pressure

    Time frame: During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min)

    mmHg

  3. Heart rate

    Time frame: During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min)

    bpm

Sponsors and collaborators

Lead sponsor

Ankara Yildirim Beyazıt University

Other

Registry information

Official study title

Relationship Between Insulin Levels and Postprandial Hypotension in the Standard Mixed Meal Test in Adults

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Oct 24, 2024
Registry last updated
Oct 24, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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