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Completed

NCT Number: NCT02381613

Postprandial Differences After Herring and Beef

While observational studies often find that diets rich in fish reduce the risk of disease, and that diets including a high intake of red meat are associated with increased risk of cardiovascular disease and cancer, the difference in health effects between red meat and fish are rarely researched in intervention studies.

The investigators hypothesise that the post-prandial plasma response of lipids and markers of cardiovascular disease risk will be more favourable after intake of herring compared to beef.

In addition, while pickling herring in a brine/sugar solution is a common form of preparation, little is known if there is a difference in potential health effects based on the preparation of herring. The investigators will compare baked and pickled herring to understand if preparation is potentially an important factor to be considered when looking at intake of fish and health.

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Key information

Age range

35 year–67 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male
  • 35-67 years
  • BMI >30 kg/m2
  • Normally eats lunch and dinner

Exclusion criteria

  • Smoke or oral tobacco use
  • Use of prescription or recreational drugs likely to interfere with primary outcome
  • Change in body weight in the month prior to the study
  • Abnormal blood biomarker values (assessed by a clinician)

Treatment and study plan

Baked beef

Other

A meal based on baked beef

Baked herring

Other

A meal based on baked herring

Pickled herring

Other

A meal based on pickled herring

Primary outcomes

  1. Omega-3 fatty acids

    Time frame: Area under the curve between 0 and 7 hours

Secondary outcomes

  1. Plasms insulin

    Time frame: Area under the curve between 0 and 7 hours

  2. Plasma triglycerides

    Time frame: Area under the curve between 0 and 7 hours

  3. Plasma lipoprotein-cholesterol

    Time frame: Area under the curve between 0 and 7 hours

  4. Plasma vitamin D

    Time frame: Area under the curve between 0 and 7 hours

  5. Plasma metabolomic profile

    Time frame: Area under the curve between 0 and 7 hours

  6. Urinary metabolomics

    Time frame: Area under the curve between 0 and 7 hours

Sponsors and collaborators

Lead sponsor

Chalmers University of Technology

Other

Collaborators

  • Oy Foodfiles Ltd

Registry information

Official study title

Postprandial Plasma Nutrient Differences Between Baked Beef, Baked Herring and Pickled Herring.

Important dates

Study start
2012
Primary completion
2013
Study completion
2015
First posted
Mar 6, 2015
Registry last updated
Mar 6, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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