Postprandial Blood Glucose and Insulin Levels Following Consumption of Lentil-containing Food Products

This study will recruit 20 healthy adults (male and female) to complete 9 study visits where they will consume different food products (chili, soup and muffin) with or without lentils incorporated into the them. Blood samples will be obtained by finger prick before and for 2 hours after the meal and analyzed for glucose and insulin.

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Key information

Conditions

Postprandial Glycemia in Healthy Adults Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Human Nutraceutical Research Unit

Guelph, Ontario, N1G 2W1, Canada

About this study

The purpose of the current study is to determine the effects of lentil-containing food products on postprandial blood glucose and insulin levels in healthy premenopausal women and men aged 18-40 years old.This study will use a randomized crossover design. Participants will complete a series of 9 study visits during which participants will consume 9 study treatment meals consisting of muffins, soup and chilli, with and without lentils. Participants will then have their blood sampled for the following 2 hours by finger prick. Participants will remain seated during the test period. All study visits will occur at the Human Nutraceutical Research Unit and be separated by a washout period of 3-7 days. Throughout the study, it will be asked that participants' lifestyle and physical activity remain unchanged. Participants will be instructed to not start any new dietary approaches, and to not start any new natural health products (unless instructed by a physician).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy men and women
Age 18-40 years (aiming for equal distribution among 18-29, 30-40 years of age)
BMI 20-30 kg/m2

Exclusion criteria

Diabetes (fasting blood glucose ≥7.0 mmol/L and/or 2hr blood glucose >11.1 mmol/L post-75g OGTT) 1
Impaired Glucose Tolerance (IGT) (Fasting blood glucose 6.1-6.9 mmol/L and/or 2hr blood glucose 7.8-11.0 mmol/L post-75g OGTT) 1
Blood pressure >140/90 mm Hg
Any major medical condition including a history of AIDS or hepatitis
Medical or surgical event requiring hospitalization within 3 months of randomization
Any medications except a stable dose (3 months) of oral contraceptives, blood pressure or statin medications
Natural health products (NHPs) used for glycemic control (all other NHPs okay as long as table for 3 months)
Tobacco use
Probiotic supplement use
Dietary fibre supplement use
Pulse consumption >4 servings per week
Food allergy or non-food life threatening allergy
Alcohol consumption >14 drinks/week or >4 drinks/sitting
Recent or intended significant weight loss or gain (>4 kg in previous 3 months)
Elite athletes
Shift workers