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OpenTrials
Completed

NCT Number: NCT00565032

Postpartum Thyroid Measures and Mood

Women with abnormal serum thyroid antibody levels or abnormal TSH and/or T4 values are more likely than their normal counterparts to have higher scores on a common postpartum depression screening test.

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Key information

Conditions

Postpartum Depression Depression, Postpartum Depressive Disorder Female Urogenital Diseases and Pregnancy Complications Mental Disorders Mood Disorders Pregnancy Complications Puerperal Disorders Urogenital Diseases

Age range

18 year–50 year

Sex eligibility

Female

Study type

Observational

Primary location

Oklahoma State University Center for Health Sciences Houston Park Obstetrics Clinic

Tulsa, Oklahoma, 74107, United States

About this study

This small pilot study was an attempt to corroborate a relationship between quantified mood and thyroid measures, using the numerical scores obtained from a common depression screen, the Edinburgh Postnatal Depression Scale (EPDS), as a continuum. Mood scores were compared with presence of thyroid autoantibodies and plasma concentrations of free T4 and TSH.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Over 18 years of age
  • In third trimester of pregnancy when recruited
  • Negative for the following drugs detected by a urine drug screen:
  • Amphetamines
  • Barbiturates
  • Benzodiazepines
  • Cocaine
  • Opiates
  • Phencyclidine metabolites (PCP), and tricyclic antidepressants
  • Vaginal delivery
  • Screened negative for major depressive disorder on the Edinburgh Postnatal Depression Scale (EPDS) at her prenatal enrollment in the study
  • Receiving a score of 12 or lower out of a possible 30

Exclusion criteria

  • Under age 18
  • Positive for any of the following drugs:
  • Amphetamines
  • Barbiturates
  • Benzodiazepines
  • Cocaine
  • Opiates
  • Phencyclidine metabolites (PCP), and tricyclic antidepressants
  • Cesarean delivery
  • EPDS score over 12 at prenatal screening test

Treatment and study plan

Primary outcomes

  1. Numerical score on the Edinburgh Postnatal Depression Scale

    Time frame: seven weeks

Sponsors and collaborators

Lead sponsor

Oklahoma State University Center for Health Sciences

Other

Registry information

Important dates

Study start
2000
Study completion
2001
First posted
Nov 29, 2007
Registry last updated
Jan 28, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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