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NCT Number: NCT07710053

Postoperative Pain and Tenesmus After Doppler-Guided Hemorrhoidal Artery Ligation With or Without Mucopexy

Hemorrhoidal disease is one of the most common anorectal disorders affecting adults worldwide. Doppler-guided hemorrhoidal artery ligation (HAL) is a minimally invasive surgical technique that has gained popularity because of its lower postoperative pain and faster recovery compared with conventional hemorrhoidectomy. In selected patients, HAL may be combined with mucopexy to address prolapsing hemorrhoidal tissue.

The aim of this prospective study is to compare postoperative pain and tenesmus between patients undergoing Doppler-guided hemorrhoidal artery ligation alone and those undergoing Doppler-guided hemorrhoidal artery ligation combined with mucopexy.

Patients diagnosed with hemorrhoidal disease and scheduled for surgical treatment at the General Surgery Department of Tokat Gaziosmanpaşa University Hospital will be enrolled after obtaining ethics committee approval and informed consent. Eligible participants will be adults aged 18 years and older without any concomitant anal canal disease. Participants will be allocated into two groups according to the surgical technique performed: (1) Doppler-guided hemorrhoidal artery ligation alone and (2) Doppler-guided hemorrhoidal artery ligation combined with mucopexy.

Postoperative pain will be assessed using a pain scale at the 8th postoperative hour and at the 1st postoperative month. Tenesmus symptoms will be evaluated and recorded at the 2nd postoperative month. The primary outcomes will be postoperative pain scores and the presence of tenesmus. Comparative statistical analyses will be performed between the two groups.

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Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥18 years
  • Diagnosis of hemorrhoidal disease requiring surgical treatment
  • Ability to provide written informed consent
  • Willingness to participate in the study.

Exclusion criteria

  • Age below 18 years
  • Presence of other anal canal diseases (anal fissure, anal fistula, anorectal malignancy, inflammatory bowel disease involving the anorectal region, etc.)
  • Previous anorectal surgery that may affect study outcomes
  • Inability or unwillingness to provide informed consent.

Treatment and study plan

HAL + Mucopexy

Procedure

Doppler-guided hemorrhoidal artery ligation will be performed using a Doppler-equipped proctoscope to identify and ligate hemorrhoidal arteries. Following arterial ligation, mucopexy will be performed to lift and secure the prolapsing hemorrhoidal mucosa.

HAL Alone

Procedure

Participants will undergo Doppler-guided hemorrhoidal artery ligation alone for the treatment of hemorrhoidal disease. Hemorrhoidal arteries will be identified using Doppler guidance and ligated without additional mucopexy.

Primary outcomes

  1. Postoperative Pain Score (VAS)

    Time frame: Postoperative Hour 8

    Assessment of pain severity using the Visual Analog Scale (VAS) at the 8th postoperative hour.

Secondary outcomes

  1. Postoperative Pain Score

    Time frame: 1 month after surgery

    Assessment of pain severity using the Visual Analog Scale (VAS) at the 1st postoperative month.

Study contacts

Contact information is provided by the study sponsor or research team.

Ali Genç, Assistant professor

CONTACT

[email protected]

+90-3562129500 ext. +90-5442280060

Muzaffer Katar, Associate Professor

CONTACT

[email protected]

0 (356) 212 95 00 - 7515

Sponsors and collaborators

Lead sponsor

Ali Genc

Other

Registry information

Official study title

Comparison of Postoperative Pain and Tenesmus Between Doppler-Guided Hemorrhoidal Artery Ligation Alone and Doppler-Guided Hemorrhoidal Artery Ligation Combined With Mucopexy in Patients With Hemorrhoidal Disease

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jul 17, 2026
Registry last updated
Jul 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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