Postoperative Effects of Propofol Versus Sevoflurane Anesthesia

Background: The choice of appropriate anesthetics is essential to protect brain function, decrease perioperative complications, and provide high-quality care, and better quality of life.

Objectives: To compare the efficacy and safety of propofol versus sevoflurane in patients undergoing elective, non-cardiac operations under general anesthesia.

Methods: This was a randomized (1:1), parallel, phase four clinical trial; carried out on 44 patients, who were candidates for elective, non-cardiac operations under general anesthesia at our hospital. Patients were randomly allocated into two equal groups in which anesthesia was maintained with propofol infusion in group P and sevoflurane inhalation in group S.

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Key information

Conditions

General Anesthetic Drug Adverse Reaction

Age range

21 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Damanhour Teaching Hospital

Damanhūr, El-Beheira, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

American Society of Anesthesiologists (ASA) physical status ≤ II
Age from 21 years
Body Mass Index (BMI) 25-35 kg/m2

Exclusion criteria

ASA physical status > II
Age < 21 years
Patients with Montreal Objective Cognitive Assessment (MoCA-B) score < 24 points
Patients with significant cardiovascular, cerebrovascular, respiratory, liver, renal, endocrine, blood, or immune diseases
Patients with visual or auditory disease, infection, chronic inflammation, disturbance of consciousness, cognitive impairment, or dementia
Patients on long-term use of sedatives or steroids, alcohol or drug abuse
Allergy to any of the study drugs

Treatment and study plan

Propofol 10 MG/ML Injection

Drug

Propofol infusion

Sevoflurane Inhalation Liquid

Drug

Sevoflurane inhalation

Primary outcomes

Mean and Standard deviation of Neuron Specific Enolase enzyme (µg/L) in blood serum (mean±SD)

Time frame: 24 hours after the end of operation

Before operation (T0), 1 hour after the end of operation (T1), 24 hours the end of operation (T2)

Sponsors and collaborators

Lead sponsor

Damanhour Teaching Hospital

Other Gov

Registry information

Official study title

Postoperative Effects of Propofol Versus Sevoflurane Anesthesia During Elective Non-Cardiac Surgeries. A Randomized Clinical Trial

Important dates

Study start: 2021
Primary completion: 2024
Study completion: 2024
First posted: Jul 7, 2023
Registry last updated: Feb 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed