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Completed

NCT Number: NCT02924532

Postoperative Dose of Parathyroid Hormone as a Marker for the Occurrence of Hypoparathyroidism After Total Thyroidectomy

The main objective of this study is to establish an optimal threshold Early parathormon (PTH) assay in order to exclude hypoparathyroidism , that is to say to obtain a negative predictive value of hypoparathyroidism highest possible.

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Key information

Conditions

Hypoparathyroidism Endocrine System Diseases Parathyroid Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de Nîmes

Nîmes, Gard, 30029, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients consecutively operated on between February 1, 2012 and December 1, 2013
  • Total thyroidectomy +/- lymphadenectomy
  • Respect of clinicobiological protocol presented above
  • The ( the ) patient ( e) was informed ( e) on the implementation of the study 's objectives, constraints and patient rights
  • The ( the ) patient ( e) is under ( e) at least 18 years

Exclusion criteria

  • The ( the ) patient ( e) is under guardianship, curatorship or under guard saves justice
  • It is not possible to give to ( the ) patient ( e) informed information
  • History of cervical radiotherapy
  • Previous history of dysfunction of the parathyroid glands
  • Previous history of surgery of the parathyroid glands
  • A history of kidney failure or hepatocellular
  • History of osteomalacia or Paget's disease
  • unhealed cancer antecedent
  • History of sarcoidosis

Treatment and study plan

immediate post operative bioassay of Parathyroid Hormone

Biological

Primary outcomes

  1. the presence/absence of hypoparathyroidism

    Time frame: day 1

    hypoparathyroidism is defined as: corrected serum calcium Day 1 <1.90 and / or symptoms of hypocalcemia (cramps, tingling of the extremities and peri-oral) to Day 1 authenticated by a VAS score> 3.

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nīmes

Other

Registry information

Official study title

Diagnostic Value of Immediate Postoperative Dose of Parathyroid Hormone as a Marker for the Occurrence of Hypoparathyroidism After Total Thyroidectomy: A Retrospective Observational Study

Important dates

Study start
2012
Primary completion
2018
Study completion
2018
First posted
Oct 5, 2016
Registry last updated
Jun 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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