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Completed

NCT Number: NCT02992600

Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes

To study on the Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes.To explore whether the olfactory dysfunction could be used as a predictor of POCD and to provide reference for POCD prevention, early detection and timely diagnosis and treatment.

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Key information

Conditions

Postoperative Cognitive Dysfunction Cognition Disorders Cognitive Dysfunction Mental Disorders Neurocognitive Disorders Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Cognitive Complications Postoperative Complications

Age range

60 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anesthesia of the Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Between 60 to 85 years old;
  • Undergoing non-cardiac and non-neurological surgery under general anesthesia;
  • Expected hospital stay ≥5 days;
  • American Society of Anesthesiologists class I or II.

Exclusion criteria

  • Mental or neurodegenerative diseases;
  • History of severe trauma or surgery within one year;
  • History of nasal or sinus illness or surgery;
  • Cold or influenza within 3 weeks;
  • Significant history of organ dysfunction;
  • Previous neuropsychological testing;
  • Difficulty to perform tests (including severe visual or auditory disorders);
  • Mini-Mental State Examination (MMSE) <24 points, <20 points if the participant only attended elementary school, or <17 points if the participant did not go to school.

Treatment and study plan

Primary outcomes

  1. the neuropsychological test battery to measure cognitive function

    Time frame: 1 day before surgery(baseline)

  2. olfaction test to measure the sense of smell

    Time frame: 1 day before surgery(baseline)

  3. the neuropsychological tests to measure cognitive function

    Time frame: within 5 to 10 days (average of 7 days) after surgery

  4. olfaction test to measure the sense of smell

    Time frame: within 5 to 10 days (average of 7 days) after surgery

Sponsors and collaborators

Lead sponsor

Han Yuan

Other

Registry information

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Dec 14, 2016
Registry last updated
Jul 25, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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