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NCT Number: NCT07359131

Postoperative Assessment of Platelet-Rich Plasma and Platelet-Rich Fibrin in Temporomandibular Joint Surgery

The goal of this observational study is to evaluate postoperative outcomes following temporomandibular joint (TMJ) surgery and to compare the effectiveness of intraoperative platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) injections in patients with temporomandibular joint disorders.

The study includes adult patients who underwent TMJ surgery and received either PRP or PRF intraoperatively. The main questions this study aims to answer are:

Whether intraoperative PRP or PRF injection is associated with differences in postoperative pain intensity and recovery.

Whether PRP and PRF differ in their effects on postoperative jaw function, including maximum mouth opening and joint symptoms.

If there is a comparison group: Researchers will compare patients who received intraoperative PRP with those who received intraoperative PRF to assess differences in postoperative pain, functional outcomes, and joint-related symptoms.

Participants will:

Have their existing medical records reviewed retrospectively.

Provide postoperative outcome data derived from routine clinical follow-up, with no prospective recruitment or intervention.

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Key information

Conditions

Temporomandibular Joint Disorders Craniomandibular Disorders Jaw Diseases Joint Diseases Mandibular Diseases Muscular Diseases Musculoskeletal Diseases Stomatognathic Diseases

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Meikun Wang

Boston, Massachusetts, 02114, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients aged 18 to 75 years (inclusive)

Underwent unilateral or bilateral temporomandibular joint (TMJ) arthroscopy

Received intraoperative platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) injection during TMJ arthroscopy

Exclusion criteria

Age younger than 18 years or older than 75 years

Did not undergo TMJ arthroscopy

Did not receive intraoperative PRP or PRF injection

Incomplete clinical or follow-up data

Treatment and study plan

Primary outcomes

  1. pain intensity

    Time frame: from baseline to 6 months post-surgery.

    The primary endpoint of the study is the change in pain intensity from baseline to 6 months post-surgery.

Secondary outcomes

  1. maximum unassisted opening (MMO)

    Time frame: baseline and various follow-up times in 6 months.

    collect data about maximum unassisted opening (MMO)

Study contacts

Contact information is provided by the study sponsor or research team.

Jingping Wang, MD PhD

CONTACT

[email protected]

6179369136

Sponsors and collaborators

Lead sponsor

Jingping Wang, MD, Ph.D.

Other

Registry information

Official study title

Postoperative Assessment in TMJ Surgery: A Comparison of the Efficacy of Intraoperative Platelet-Rich Plasma and Platelet-Rich Fibrin Injections

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jan 22, 2026
Registry last updated
Jun 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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