Skip to main content
OpenTrials
Completed

NCT Number: NCT06498557

Postoperative Analgesis in Total Knee Arthroplasty

Postoperative analgesic treatment methods are applied to patients who have undergone knee arthroplasty. These applications are a routine part of the procedure. It is medically and ethically necessary. Postoperative analgesia applications are started during the intraoperative period and continued during the postoperative period. The analgesia protocol to be used is shaped by the characteristics of the patient and the skill and experience of the anesthesiologist. The scientifically accepted method is multimodel analgesia protocols. These protocols cover a wide range from paracetamol to opioids to peripheral and central blocks (methods such as suprainguinal fascia iliac block (SFIP), adductor block (ACB) and infiltration analgesia (IPACK) applied between the posterior elements of the knee and the popliteal artery). Our aim in this study is to evaluate the effects of analgesia protocols applied to patients undergoing knee arthroplasty surgery on inflammatory biomarkers (such as neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), systemic immune inflammation score (SII), lactate) obtained from routine blood and blood gas examinations in the first 24 hours of the postoperative period.

Completed

Looking for future studies?

Notify Me

Key information

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

SAMSUN UNIVERSITY Samsun Training and research hospital

Samsun, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-75 years old
  • ASA I,II,III patients
  • Patients who will undergo elective surgery

Exclusion criteria

  • Patients undergoing emergency surgery
  • Patients with bleeding diathesis
  • Those who are allergic or sensitive to local anesthetics and opioid drugs,
  • Those who use gabapentinoids
  • Patients with neurocognitive disorders,
  • Patients with chronic organ failure,
  • Mothers with suspected pregnancy, pregnant or breastfeeding mothers
  • Patients using opioids
  • Those who use steroids
  • Those with a history of substance use

Treatment and study plan

Peripheral nerve block methods

Other

We apply different nerve blocks to patients for analgesic purposes after knee replacement surgery. These blocks are a combination of SFIP block and adductor channel block and iPACK block.

Primary outcomes

  1. Postoperative pain

    Time frame: postoperative 24 hours

    Pain levels of patients will be evaluated with the Numerical Pain Scale (NRS) in the first 24 hours postoperatively.

Secondary outcomes

  1. inflammatory mediators

    Time frame: preoperative 24 hours

    NLR

  2. inflammatory mediators

    Time frame: preoperative 24 hours

    PLR

  3. inflammatory mediators

    Time frame: preoperative 24 hours

    SII

  4. inflammatory mediators

    Time frame: preoperative 24 hours

    Lactate

Sponsors and collaborators

Lead sponsor

Senay Canikli

Other

Registry information

Official study title

Results of Postoperative Analgesis Protocols Applied in Total Knee Arthroplasty:Observational Study

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jul 12, 2024
Registry last updated
Nov 25, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.