Postoperative Analgesia and Recovery Quality in Total Thyroidectomy

This prospective observational study evaluates the association between postoperative analgesic approaches and recovery outcomes in patients undergoing elective total thyroidectomy. Patients will be followed under routine clinical care without intervention or randomization.

The primary outcome is the Quality of Recovery-15 (QoR-15) score at 24 hours. Secondary outcomes include swallowing pain, resting pain, opioid consumption, postoperative nausea and vomiting, and additional analgesic requirement.

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Key information

Conditions

Postoperative Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Istinye Üniversity

Istanbul, Merkez Mahallesi, 34250, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients aged 18-75 years
ASA physical status classification I-III
Patients scheduled for elective bilateral total thyroidectomy
Patients undergoing surgery under general anesthesia
Individuals able to read and understand Turkish and cognitively capable of completing the QoR-15 questionnaire
Patients providing written informed consent to participate in the study

Exclusion criteria

Chronic opioid use (≥3 months of regular opioid use)
Presence of chronic pain syndrome
Psychiatric illness or cognitive impairment
History of neurological disease (stroke, dementia, Parkinson's disease, etc.)
Known allergy to local anesthetic agents
Previous surgical interventions in the cervical region (including revision thyroid surgery)
Planned extended surgery with concomitant neck dissection
Substernal/retrosternal goiter cases (with potential need for sternotomy or additional procedures)
Emergency surgical procedures
Patients with ASA physical status IV or higher
Pregnancy
Patients expected to require postoperative intensive care
Patients experiencing intraoperative complications that deviate from the standard monitoring protocol

Treatment and study plan

cervical plexus block

Other

Bilateral intermediate cervical plexus block may be performed as part of routine clinical practice based on the attending anesthesiologist's decision. The study is observational, and no intervention, assignment, or protocol-driven procedure is applied. Patients are managed according to standard perioperative care.

Primary outcomes

Quality of Recovery-15 (QoR-15) Total Score

Time frame: 24 hours postoperatively

Quality of recovery will be assessed using the QoR-15 questionnaire. The total score ranges from 0 to 150, with higher scores indicating better recovery. The outcome will be compared between patients who received cervical plexus block and those who did not.

Study contacts

Contact information is provided by the study sponsor or research team.

İlke Dolgun

CONTACT

[email protected]

05555485632

Sponsors and collaborators

Lead sponsor

Istinye University

Other

Registry information

Official study title

Association Between Postoperative Analgesic Approaches and Quality of Recovery and Swallowing Pain in Patients Undergoing Elective Total Thyroidectomy: A Prospective Observational Study

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Apr 23, 2026
Registry last updated: Apr 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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