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NCT Number: NCT06672614

Postexercise Hot-Water Immersion on Exercise Performance in Hypoxia

The purpose of this study is to determine the effect of 5 days post-exercise hot water immersion on exercise performance at simulated altitude.

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Key information

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Nipissing University

North Bay, Ontario, P1B 8L7, Canada

About this study

Human performance is compromised at altitude due to a lower partial pressure of oxygen and subsequent reductions in the convective transport of oxygen to tissue. Long-term acclimation to attitude incurs physiological adaptations that result in a near return to sea-level performance; however, the time required (~2 weeks) for such adaptations is often logistically challenging for athletes, military personnel or other individuals who reside at sea level. Recent research suggests that physiological acclimation to heat stress (i.e., heat acclimation) and altitude (i.e., hypoxia) share similar cellular adaptations, namely an up-regulation of Hypoxia-inducible factor 1 (HIF-1) and various heat shock proteins. Therefore, it is hypothesized that heat acclimation may provide physiological protection from reduced oxygen transport to the tissue and enhance performance at altitude. This cross-tolerance model is supported by traditional heat acclimation protocols (i.e., submaximal exercise in hot ambient temperature); however, it has not been tested with passive exposure to heat stress through post-exercise hot water immersion.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Physically active (minimum of 90 minutes of moderate-intensity exercise per week)

Exclusion criteria

  • Cardiovascular disease
  • resident of >1500 m above sea-level in the past year;
  • history of fainting

Treatment and study plan

Post-Exercise Hot Water Immersion

Other

Participants will cycle for 60 minutes at 50% of maximal oxygen uptake (VO2 max) followed by 30 minutes post-exercise hot water immersion (40oC) for 5 consecutive days.

Control Group

Other

Participants will cycle for 60 minutes at 50% maximal oxygen uptake (VO2 max) for 5 consecutive days. There is no water immersion following the exercise.

Primary outcomes

  1. Time-Trial Performance in hypoxia conditions

    Time frame: 30 minutes

    Results of a 16 km time-trial test conducted at an fraction of inspired oxygen (FiO2) of 0.14

Secondary outcomes

  1. Pulse oxygen saturation during exercise

    Time frame: 30 minutes

    Capillary oxygen saturation measured on the earlobe throughout the time-trial tests using pulse oximetry.

  2. Skin temperature during exercise

    Time frame: 90 minutes

    Skin temperature measured throughout the time trial-tests and exercise training intervention using temperature probes attached to the calf, thigh, chest and arm, from which weighted averages are calculated.

  3. Core temperature during exercise

    Time frame: 90 minutes

    Core body temperature measured throughout the time-trial tests and exercise training interventions using a rectal temperature probe.

  4. Heart Rate during exercise

    Time frame: 90 minutes

    Heart rate will be measured throughout the time trial tests and exercise training interventions using a wireless (Polar) heart rate chest strap.

Study contacts

Contact information is provided by the study sponsor or research team.

Geoffrey L Hartley, PhD

CONTACT

[email protected]

705 845-3887

Sponsors and collaborators

Lead sponsor

Nipissing University

Other

Registry information

Official study title

Effect of Five Days of Postexercise Hot-Water Immersion on Exercise Performance in Hypoxia

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Nov 4, 2024
Registry last updated
Nov 4, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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