Posterior Circulation ASTRAL Prognostic Score

The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke prognosis, intracranial occlusion, recanalization and stroke recurrences. The main question it aims to answer is the modified Rankin score in 3 months after the event.

Participants will be patients with acute ischemic stroke of the posterior circulation with mRS priot to event <3. All the data will be collected retrospectively from patients included in the ASTRAL registry between January 2003 and December 2021. The ASTRAL registry will be used as the derivation cohort of the score. Demographics, acute glucose, NIHSS score and acute imaging of each participant will be used from the derivation cohort in order to create an integer-based prognostic score. After internal validation, we plan to validate the score in external stroke registries to show its validity.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Stroke Ischemic Brain Diseases Brain Infarction Brain Ischemia Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Infarction Ischemia Ischemic Stroke Necrosis Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Posterior Circulation Brain Infarction Risk Score Stroke Stroke Acute Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

First Propedeutic Department of Internal Medicine & Stroke Unit, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Central Macedonia, Greece

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Isolated posterior circulation strokes based on clinical or/and imaging evidence.
Arriving within 24h at hospital since last proof of good health.

Exclusion criteria

no available data for 3 months modified Rankin Score
modified Rankin Score≥3 prior the event

Treatment and study plan

ASTRAL prognostic score

Diagnostic Test

ASTRAL prognostic score

Primary outcomes

3 months modified Ranking scale

Time frame: January 2003-December 2021

evaluation of 3 months neurological disability

Sponsors and collaborators

Lead sponsor

University of Thessaly

Other

Collaborators

Centre Hospitalier Universitaire Vaudois
University of Lausanne

Registry information

Official study title

Pc-ASTRAL Score for the Prediction of 3 Months Functional Outcome in Acute Ischemic Stroke at the Posterior Circulation

Important dates

Study start: 2003
Primary completion: 2021
Study completion: 2025
First posted: Jun 15, 2023
Registry last updated: Apr 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Active, Not Recruiting