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Completed

NCT Number: NCT02491580

Post-transplant Cancer Incidence and Survival in Patients With or Without Pre-transplant Cancer

Patients with previous malignancies have increasingly been accepted for renal transplantation. However, post-transplant malignancy risk and survival rates of these patients are unknown. Our aim was to assess if previous malignancies pose an unnecessarily high risk of post-transplant malignant tumours and if the organs as a resource are too limited for investment in this patient group.

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Key information

Conditions

Neoplasms Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Kidney Failure Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Uppsala University, Department of Surgical Sciences, Section of Transplantation Surgery

Uppsala, SE-751 85, Sweden

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Kidney transplanted patients from January 1982 through December 2013 with or without a pre transplant cancer.

Exclusion criteria

  • Simultaneous kidney+pancreas transplantation.
  • Islet cell transplanted patients
  • Undiagnosed malignancies at the time of transplantation
  • Death within a week after transplantation
  • First transplantation at another hospital

Treatment and study plan

Primary outcomes

  1. Incidence of post-transplant cancer

    Time frame: Up to 33 years starting in January 1982.

Secondary outcomes

  1. Patient survival

    Time frame: Up to 33 years starting in January 1982.

  2. Cancer-induced mortality

    Time frame: Up to 33 years starting in January 1982.

Other outcomes

  1. Graft survival

    Time frame: Up to 33 years starting in January 1982.

Sponsors and collaborators

Lead sponsor

Uppsala University

Other

Registry information

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Jul 8, 2015
Registry last updated
Jul 8, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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