Dexmedetomidin
Drug•Group D (Dexmedetomidine Group): 0.5 µg/kg dexmedetomidine diluted in 100 mL of normal saline.
Not Yet Recruiting
NCT Number: NCT07377903
Post Operative Shivering Following Anesthesia
The aim of this study is to compare the efficacy of magnesium sulphate, ondansetron, and dexmedetomidine in managing post-spinal anesthesia shivering. The primary aim is the time to cessation of shivering after drug administration, while secondary aim include hemodynamic parameters (heart rate, blood pressure, SpO₂ ) and the recurrence of shivering
Not Yet Recruiting
Trial opening soon.
Get NotifiedKey information
Conditions
Age range
18 year–45 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
About this study
This is a randomized double blinded study including patients undergoing surgery under spinal anesthesia. Patients will be randomly allocated into three groups to receive magnesium sulphate, ondansetron, or dexmedetomidine for the treatment of post-spinal anesthesia shivering. The time to cessation of shivering, hemodynamic parameters, and recurrence of shivering will be recorded.
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Age from 18 to 45 years.
- Both sexes.
- American Society of Anesthesiologists physical status I, II
- Scheduled for elective lower abdominal or lower limb surgeries under spinal anesthesia
Exclusion criteria
- Patients with known allergy to study drugs.
- Patients with baseline body temperature outside the normal range (36-37.5°C).
- History of thermoregulatory disorders, thyroid dysfunction, or neurological diseases.
- Patients receive sedatives, antipsychotics, or antidepressants.
- Patients require intraoperative conversion to general anesthesia.
Treatment and study plan
Mg (magnesium sulfate)
Drug50 mg/kg magnesium sulphate diluted in 100 mL of normal saline.
Ondansetron 8 mg
Drug8 mg ondansetron diluted in 100 mL of normal saline.
Primary outcomes
-
Time to cessation of shivering after drug administration.
Time frame: 6 hours
Grade 0: No shivering.
- Grade 1: Piloerection or peripheral vasoconstriction but no visible shivering. 4
- Grade 2: Muscular activity in only one muscle group.
- Grade 3: Muscular activity in more than one muscle group.
- Grade 4: Whole-body shivering.
Study contacts
Contact information is provided by the study sponsor or research team.
Ahmed Elsaied Abd Elrahman, Professor
CONTACT
01118011611 ext. 01095848062
Aya Mohammed Aboelwafa, Resident of anesthesia
CONTACT
01095848062 ext. 01002181828
Sponsors and collaborators
Lead sponsor
Sohag University
Other
Registry information
Official study title
Pharmacological Management of Post Operative Shivering Following Anesthesia
Important dates
- Study start
- 2026
- Primary completion
- 2026
- Study completion
- 2026
- First posted
- Jan 30, 2026
- Registry last updated
- Feb 4, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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