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Completed

NCT Number: NCT04441736

Post -Extubation Respiratory Failure

comparing high flow nasal cannula , conventional oxygen tharapy and non invasive ventilation post-extubation period for patients mechanically ventilated due to respiratory failure regarding re-intubation rate, ICU outcome & 28 days mortality

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Key information

Conditions

Respiratory Insufficiency Respiration Disorders Respiratory Tract Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Medicine

Giza, 11345, Egypt

About this study

patients with respiratory failure either type I or type II planned for extubation will be divided into 3 groups post extubation :

Group I: will receive high flow nasal cannula giving oxygen 60 litres / minute flow group II: will receive nasal cannula up to 10 litres / minute group III: will receive non invasive ventilation

Data of the patients will be collected for 28 days post-extubation and analysed

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • respiratory failure type I and Type II

Exclusion criteria

  • Mechanical ventilation due to other cause such as disturbed conscious level or respiratory muscle weakness

Treatment and study plan

High Flow Nasal Cannula

Device

Device gives high flow oxygen comparable to non invasive ventilation and conventional oxygen therapy

Other names: Non invasive ventilation

Primary outcomes

  1. Number of participants with post extubation respiratory failure

    Time frame: 7 days

    Number of participants with post extubation hypoxemia with or without hypercapnea

Secondary outcomes

  1. Rate of ICU stay and mortality

    Time frame: 28 days

    Duration of ICU stay and incidence of mortality

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Different Oxygenation Modalities for Early Post Extubation Failure

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Jun 22, 2020
Registry last updated
May 31, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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