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OpenTrials
Completed

NCT Number: NCT01531855

Post-exercise Insulin Reductions in Type 1 Diabetes

The investigators hypothesise that reducing rapid-acting insulin dose after exercise will help prevent Type 1 diabetes individuals experiencing hypoglycaemia.

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Key information

Conditions

Type 1 Diabetes Autoimmune Diseases Behavior Diabetes Mellitus Diabetes Mellitus, Type 1 Endocrine System Diseases Glucose Metabolism Disorders Immune System Diseases Metabolic Diseases Motor Activity Nutritional and Metabolic Diseases

Age range

18 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Clinical Research Facility

Newcaslte Upon Tyne, Tyne and Wear, NE1 4LP, United Kingdom

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • T1DM,
  • Male,
  • basal-bolus regimen (insulin glargine / detemir with insulin lispro / aspart),
  • HbA1c < 9.9%,
  • aged 18-50.

Exclusion criteria

  • HbA1c > 10%,
  • not treated with basal-bolus (insulin glargine / detemir with insulin lispro / aspart),
  • aged <18 > 50.

Treatment and study plan

Reducing post-exercise rapid-acting insulin (insulin lispro or aspart) dose

Other

Dosage after exercise

Primary outcomes

  1. 24 hour blood glucose area under the curve

    Time frame: 24 hours

    24 hour, post-exercise, glucose area under the curve.

Secondary outcomes

  1. Ketogenesis

    Time frame: 60 minutes before and 24 hours post-exercise

    Blood beta-hydroxybutyrate concentrations

Sponsors and collaborators

Lead sponsor

Northumbria University

Other

Collaborators

  • Diabetes UK

Registry information

Official study title

The Metabolic and Glycaemic Responses to Reductions in Rapid-acting Insulin Dose After Running Exercise in People With Type 1 Diabetes Mellitus.

Important dates

Study start
2012
Primary completion
2012
Study completion
2012
First posted
Feb 13, 2012
Registry last updated
Aug 4, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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