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Completed

NCT Number: NCT03615625

Post-exercise Hypotension After a Power Training Session in Older Adults With Hypertension

The main purpose of the present study was to evaluate the effect of a power training session on office and 24h ambulatory blood pressure in older adults with hypertension. As secondary outcomes, the investigators compared post-exercise hypotension, BP variability, and endothelial function between older men and women with hypertension.

The working hypothesis was that a single bout of power exercise would decrease both office and 24 h BP in comparison to a non-exercising control session and men and women would respond differently after a power training session.

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Key information

Age range

60 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hospital de Clinicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

About this study

Participants randomly performed two experimental sessions: power exercise training (PT) and non-exercising control at seated rest (Con). They maintained their current antihypertensive medications throughout the trial. Each session was composed of 20 min of rest in the supine position, 40 min of PT or Con protocols, and 60 min of rest in supine position after protocols. The PT was composed of 3 sets of 8-10 repetitions of 5 exercises performed in the following order: leg press, bench press, knee extension, upright row, and knee flexion, using an intensity corresponding to 50 % of 1-RM and two-minute intervals between sets and exercises. The concentric phase of exercises during each repetition was performed "as fast as possible" while the eccentric phase lasted 1-2 seconds. During the Con, the participants remained seated rest on the same exercise machines, but without any exercise. Standardized office BP was performed before and during the first hour (in intervals of 15 min) after exercise and control sessions. Together with the office BP evaluation in the pre and post sessions, the endothelium-dependent brachial vascular function was evaluated using Flow-mediated dilation. Afterwards, participants underwent 24h ambulatory BP monitoring..

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Office blood pressure between 130-179 and 80-110 mmHg for systolic and diastolic blood pressure, respectively;
  • Non-engaged in structured programs of exercise for the last 3 months since the beginning of this study;
  • Able to perform the proposed exercises.

Exclusion criteria

  • Underlying cardiovascular disease previously diagnosticated by a doctor, occurred in the last 24 months, such as: acute myocardial infarction, angina, stroke or heart failure;
  • Diseases that reduce life expectancy;
  • Smokers and ex-smokers for less than six months;
  • BMI > 39.9 kg/m²
  • diabetic proliferative retinopathy.

Treatment and study plan

Power Training Session

Behavioral

3 sets of 8-10 repetitions of 5 exercises performed in the following order: leg press, bench press, knee extension, upright row, and knee flexion, using an intensity corresponding to 50 % of 1-RM and two-minute intervals between sets and exercises. The concentric phase of exercises during each repetition was performed "as fast as possible" while the eccentric phase lasted 1-2 seconds.

Primary outcomes

  1. Ambulatory Blood Pressure Monitoring

    Time frame: 24 hours after control and power training exercise session

    Mean 24-h, day-time, night-time of blood pressure in mmHg will be assessed after each experimental session (power training session and control session)

Secondary outcomes

  1. Office Systolic Blood Pressure

    Time frame: 60 minutes after control and power training exercise session

    Systolic blood pressure in mmHg will be measured using automatic oscillometric before and after each experimental session throughout one hour

  2. Office Diastolic Blood Pressure

    Time frame: 60 minutes after control and power training exercise session

    Diastolic blood pressure in mmHg will be measured using automatic oscillometric before and after each experimental session throughout one hour

  3. Endothelial Function

    Time frame: 60 minutes after control and power training exercise session

    Flow-mediated dilatation (FMD) assessed through high resolution ultrasonography before and after each experimental session throughout one hour

  4. Blood Pressure Variability

    Time frame: 24 hours after control and power training exercise session

    Systolic and diastolic BP values obtained in the 24-hour ambulatory blood pressure monitoring, with valid measures included in a programmed software to calculate the average real variability of these measures.

Other outcomes

  1. Sex Differences in Ambulatory Blood Pressure Monitoring, Office Blood Pressure, Endothelial Function and Blood Pressure Variability

    Time frame: 60 minutes and 24 hours after control and power training exercise session

Sponsors and collaborators

Lead sponsor

Hospital de Clinicas de Porto Alegre

Other

Collaborators

  • Federal University of Rio Grande do Sul

Registry information

Official study title

Effect of a Power Training Session on Ambulatory Blood Pressure in Older Adults With Hypertension: a Randomized Crossover Trial

Important dates

Study start
2018
Primary completion
2019
Study completion
2020
First posted
Aug 6, 2018
Registry last updated
Jan 14, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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