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OpenTrials
Completed

NCT Number: NCT06170034

Post-emergency Management of Patients With Transient Ischemic Attack

A transient ischemic attack (TIA) is a momentary neurological dysfunction due to a brief cessation of blood flow to a region of the brain, resulting in typical signs of stroke (hemiplegia, aphasia, dysarthria), but whose clinical symptoms typically last less than an hour, with no visible lesion on imaging. This diagnosis remains difficult and is essentially based on the clinical judgment of the physician.

Because a TIA can be a "pre-alarm" for stroke in 20-30% of cases, it needs to be treated appropriately and as early as possible in the emergency department. Stroke rates after untreated TIA are 5% within 48 hours, 10% within one month and 20% within one year. This risk is calculated using the ABCD² score which is based on the patient's risk factors and the clinical manifestations of TIA. Patients with a score ≥ 3 should be hospitalized as soon as possible for a complete medical evaluation. However, this score has not been scientifically validated, and several specialists agree that all TIAs should be evaluated immediately. Preventing stroke is a major public health issue because it is a serious, disabling and sometimes fatal disease. Given the seriousness of the progression from TIA to stroke, the French National Authority for Health has issued a series of management recommendations. However, in practice, these guidelines remain complicated to follow and patients management may vary and be more or less effective.

Therefore, the aim of this study is to highlight the differences in how inpatients and outpatients are managed. Following these observations, solutions will be sought to make the care and management of these patients more efficient and more in line with recommendations.

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Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient over 18 years old.
  • Consultation in the emergency department.
  • Suspected TIA diagnosed by emergency physician.
  • Duration of TIA symptoms <1 hour.

Exclusion criteria

  • Validation MRI performed prior to suspected TIA.
  • Patient hospitalized for a condition other than TIA, including stroke.
  • Patient referred to another hospital for further examination.
  • Pregnant women.
  • Patient unable to understand and answer a questionnaire.
  • Patient under legal protection.

Treatment and study plan

Satisfaction questionnaire

Behavioral

Satisfaction questionnaire to assess how TIA patients feels about their medical care.

Medical care questionnaire

Other

Recording appointments and results of examinations and consultations in TIA management

Primary outcomes

  1. Assess time between arrival in the emergency department for suspected TIA patients and MRI.

    Time frame: Baseline

Secondary outcomes

  1. Time between arrival in the emergency department and MRI by departments.

    Time frame: Baseline

  2. Time between arrival in the emergency department and MRI by ABCD² score.

    Time frame: Baseline

  3. Percentage of patients with complete TIA management by departments.

    Time frame: Baseline

  4. Hospitalization times according to care units

    Time frame: Baseline

  5. Hospitalization times according to complete TIA management

    Time frame: Baseline

  6. Percentage of patients with secondary event, according to complete TIA management

    Time frame: Baseline

  7. Number of outpatients without complete TIA management one month after TIA.

    Time frame: At 1 month follow-up

  8. Patient satisfaction with a short questionnaire

    Time frame: At 1 month follow-up

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Henri Duffaut - Avignon

Other

Registry information

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Dec 14, 2023
Registry last updated
Jan 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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