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OpenTrials
Completed

NCT Number: NCT07571382

Post-Covid-19 Patients Follow-up Study

Taste, smell, trigeminal and salivary function is impacted in post-COVID-19 patients

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Key information

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-COVID-19 diagnosis

Exclusion criteria

-Not COVID-19 diagnosis

Treatment and study plan

Smell training

Other

Smell training

Primary outcomes

  1. Smell

    Time frame: two years

    Olfactory (smell) function will be evaluated using the Twelve felt-tip Sniffin' Sticks test (Burghart Messtechnik GmbH, Holm, Germany). Participants are categorized into anosmic (score 0-6, no smell), hyposmic (score 7-10, reduced smell), and normosmic (score 11-12, normal smell), according to normative classification.

Secondary outcomes

  1. Taste

    Time frame: 2 years

    Gustatory (taste) function is assessed using Taste Strips impregnated with solutions of four different taste qualities (sweet, sour, salty, and bitter) in four different concentrations (Burghart Messtechnik GmbH, Holm, Germany). Participants are classified into ageusic (score 0, no taste), hypogeusic (score 1-8, reduced taste) and normogeusic (score 9-16, normal taste) using a normative classification. Participants are considered to have a specific ageusia if they are unable to detect all four different concentrations of a particular tastant.

  2. Dry mouth

    Time frame: 2 years

    Xerostomia (oral dryness) iss categorized according to participants' self-reported perception as either no dry mouth (score 0), or dry mouth (score 1). Participants are asked whether the symptoms of xerostomia started before or after COVID-19 infection and are asked open-ended questions where they could describe their experience of oral dryness. Finally, they are asked to report whether there are food items that they had to refrain from eating because of parosmia, dysgeusia, dysesthesia or xerostomia.

  3. Dysesthesia

    Time frame: 2 years

    Dysesthesia (oral burning sensation) iss categorized as either no dysesthesia (score 0), or dysesthesia (score 1). Participants report how often they experienced dysesthesia (constantly, daily, sometimes, periodically, during meals, in between meals), asked to describe where in the mouth they experienced dysesthesia (whole tongue, anterior tongue, lips, palate, buccal mucosa, other), and identify food items that enhanced the dysesthesia (spicy, sweet, sour, salty, bitter).

Sponsors and collaborators

Lead sponsor

University of Oslo

Other

Registry information

Official study title

Occurrence and Clinical Management of Chemosensory, Trigeminal, and Salivary Dysfunctions in Post-COVID-19 Patients

Acronym: COVID-19

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
May 6, 2026
Registry last updated
May 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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