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NCT Number: NCT03853057

Positive Pressure and Gravity Affect Volumetric Capnography

Volumetric capnography is an interesting and non-invasive tool for monitoring ventilation in mechanically ventilated patients. The aim of this study was to test the effect of positive pressure ventilation and different body positions on volumetric capnograms.

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Key information

Conditions

Hypoventilation Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Insufficiency Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

28 year–39 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Hospital Privado de Comunidad

Mar del Plata, Buenos Aires, 7600, Argentina

About this study

In this interventional study awake and healthy volunteers will be submitted to spontaneous, pressure support and control pressure ventilation using a tight nasal mask. Volumetric capnography and electrical impedance tomography (EIT) will be continuously recorded during the protocol. Different body positions were randomly tested. Analysis of global and regional distribution of ventilation using EIT will be matched with changes observed in volumetric capnography-derived parameters.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • American Society Anesthesia physical status I.
  • Age between 25-39 years old,
  • Body mass index between 23-28 kg/m2,
  • Non-smokers.

Exclusion criteria

  • Presence of pulmonary or cardiac diseases.
  • Abnormal spirometry.

Treatment and study plan

body positions

Other

positive pressure ventilation at different body positions

Primary outcomes

  1. Analysis of the changes in volumetric capnographic parameters with changes in body positioning and positive pressure ventilation.

    Time frame: 4 hours

    The volunteers are breathing spontaneously with and without positive pressure support. Capnographic parameters were registered at each studied condition.

Secondary outcomes

  1. Electrical impedance images of the distribution of ventilation with changes in body positioning and positive pressure ventilation.

    Time frame: 4 hours

    The volunteers are breathing spontaneously with and without positive pressure support. Electrical impedance images were taken at each studied condition.

Sponsors and collaborators

Lead sponsor

Hospital Privado de Comunidad de Mar del Plata

Other

Registry information

Official study title

The Effect of Positive Pressure and Body Position on Volumetric Capnography Assessed by Electrical Impedance Tomography

Important dates

Study start
2016
Primary completion
2019
Study completion
2019
First posted
Feb 25, 2019
Registry last updated
Feb 25, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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