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OpenTrials
Completed

NCT Number: NCT01652612

Positive End-expiratory Pressure and Alveolar Recruitment for One Lung Ventilation

Hypoxia frequently develops during one lung ventilation in the supine position.The objective of this article is to study the impact of preemptive alveolar recruitment and subsequent positive end expiratory pressure on arterial oxygenation and lung mechanics during one lung ventilation in the supine position in patients undergoing thoracic surgery .

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Key information

Conditions

One Lung Ventilation

Age range

20 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Yong Seon Choi

Seoul, South Korea

About this study

outcome measures: respiratory parameters (Paw, Ppla, Compliance, Vd/Vt)and oxygenation parameters (PaO2, shunt fraction, Pa-AO2)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I-II
  • age: 20-75 years

Exclusion criteria

  • moderate to severe impaired respiratory function,
  • heart failure,
  • patients' refusal

Treatment and study plan

PEEP

Other

8 cmH2O PEEP throughout the period of OLV and 2nd TLV

Primary outcomes

  1. PaO2, number of patients with hypoxia (PaO2< 90mmHg)

    Time frame: participants will be followed for the duration of anesthesia, an expected average of 3 hours

    blood samplings after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV

Secondary outcomes

  1. intrapulmonary shunt

    Time frame: participants will be followed for the duration of anesthesia, an expected average of 3 hours

    blood sampling after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Official study title

Effects of Positive End-expiratory Pressure and Alveolar Recruitment on the Oxygenation and Respiratory Mechanics During One-lung Ventilation in the Supine Position

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Jul 30, 2012
Registry last updated
Jul 4, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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