Queen Alexandra Hospital
Portsmouth, Hampshire, PO6 3LY, United Kingdom
Location status: Recruiting
Location contact
Paul E Schmidt
CONTACT
Paul E Schmidt
PRINCIPAL_INVESTIGATOR
Recruiting
NCT Number: NCT04983082
Portsmouth CORE-D Routine Care Data Repository
An integrated database of depersonalised routine hospital patient data consisting of demographic and disease attributes, physiological or laboratory measurements, care contacts and interventions along with associated clinical outcomes. The database is an essential resource for the development and testing of risk models and classification systems, modified as necessary for patient subgroups, which can then be introduced into clinical care to improve patient outcomes. It can also be used for large scale simulations to evaluate interventions.
Recruiting
Interested in participating?
Request InfoKey information
Age range
16 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
About this study
The aims and objectives of this database of depersonalised routinely collected hospital patient data are to:
- Conduct epidemiological and observational studies of acute hospital care.
- Develop and use algorithms and risk models to identify the deteriorating / sick adult so that interventions and enhanced care can be provided in a timelier manner with consequent resource and outcome improvements. This covers both the deteriorating inpatient at risk of adverse outcomes and people in the local community at risk of hospitalisation or in need of other health services.
- Retrospectively evaluate interventions e.g. impact of system-wide clinical pathway introduction
- Conduct simulations of clinical pathways
Who can participate
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Adult presenting at the acute hospital or receiving services from the hospital
Exclusion criteria
- Adults who have registered an opt out of research with National Health Service (NHS) Digital
- Adults who have contacted the hospital to ask that their records are not to be included in this study
Treatment and study plan
Primary outcomes
-
In-hospital death
Time frame: At 24 hours after an observation assessment or physiological measurement
Death during hospital admission
-
In-hospital death
Time frame: 30 days after admission
Death during hospital admission
-
Unanticipated ICU admission
Time frame: At 24 hours after an observation assessment or physiological measurement
Unanticipated ICU admission during hospital stay
-
Unanticipated ICU admission
Time frame: 30 days after admission
Unanticipated ICU admission during hospital stay
-
Cardiac arrest
Time frame: At 24 hours after an observation assessment or physiological measurement
Cardiac arrest during hospital stay
-
Cardiac arrest
Time frame: 30 days after admission
Cardiac arrest during hospital stay
Secondary outcomes
-
Diagnosis of Corona Virus Disease (COVID) infection
Time frame: 48 hours after presentation
Diagnosis of COVID-19
-
Diagnosis of Corona Virus Disease (COVID) infection
Time frame: At 48 hours after an observation assessment or physiological measurement
Diagnosis of COVID-19
-
Detection of Acute Organ Dysfunction
Time frame: 24 hours after presentation
Detection of acute organ dysfunction as measured by components of the Sequential Organ Failure Assessment (SOFA) Score
-
Detection of Acute Organ Dysfunction
Time frame: 48 hours after presentation
Detection of acute organ dysfunction as measured by components of the Sequential Organ Failure Assessment (SOFA) Score
-
Detection of Acute Organ Dysfunction
Time frame: 72 hours after presentation
Detection of acute organ dysfunction as measured by components of the Sequential Organ Failure Assessment (SOFA) Score
-
Detection of Acute Organ Dysfunction
Time frame: 1 week after presentation
Detection of acute organ dysfunction as measured by components of the Sequential Organ Failure Assessment (SOFA) Score
-
Detection of Acute Organ Dysfunction
Time frame: 30 days after presentation
Detection of acute organ dysfunction as measured by components of the Sequential Organ Failure Assessment (SOFA) Score
Study contacts
Contact information is provided by the study sponsor or research team.
Alice Mortlock, PhD
CONTACT
023 92286000 ext. 4042
Paul Meredith, PhD
CONTACT
023 92286000 ext. 3774
Sponsors and collaborators
Lead sponsor
Portsmouth Hospitals NHS Trust
Other Gov
Registry information
Official study title
Portsmouth Clinical Outcomes REsearch Database (CORE-D)- a Research Database of Routine Electronically Recorded Patient Data to Model Adverse Clinical Outcomes and Healthcare Resource Usage
Acronym: CORE-D
Important dates
- Study start
- 2021
- Primary completion
- 2031
- Study completion
- 2031
- First posted
- Jul 30, 2021
- Registry last updated
- Jun 29, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.