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Completed

NCT Number: NCT05749198

Portal Hypertension Using Magnetic Resonance Elastography

This prospective study was conducted in a tertiary university hospital. The investigators researched the correlation between MRE-assessed stiffness of the liver and spleen and the Hepatic venous pressure gradient (HVPG) values. Furthermore, the investigator evaluated whether MRE-assessed stiffness reflected changes in portal hypertension (PH) after administering non-selective beta-blockers (NSBBs).

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Key information

Conditions

Portal Hypertension Digestive System Diseases Hypertension, Portal Liver Diseases Magnetic Resonance Imaging

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Wonju Severance Christian Hospital

Wŏnju, Gangwon-do, 22070, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosed liver cirrhosis
  • requiring prophylactic treatment of esophageal varices

Exclusion criteria

  • the coexistence of hepatocellular carcinoma
  • refractory ascites who regularly underwent large-volume paracentesis
  • the use of selective beta-blocker or carvedilol therapy for at least 4 weeks
  • undergoing liver transplantation
  • contraindication with magnetic resonance imaging

Treatment and study plan

MRE

Diagnostic Test

MRE was performed using a 3T system (Magnetom Skyra; Siemens, Erlangen, Germany) equipped with a combination of a 30-channel body and a 32-channel spine matrix coil.

Primary outcomes

  1. Change of liver stiffness and spleen stiffness by MRE

    Time frame: Change from baseline stiffness of MRE at 6 months

  2. The change of portal pressure (HVPG) prior to and after treatment with NSBB

    Time frame: Change from baseline and at 6 months

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Official study title

Non-invasive Assessment of Portal Hypertension Using Quantitative Magnetic Resonance Imaging

Important dates

Study start
2018
Primary completion
2019
Study completion
2023
First posted
Mar 1, 2023
Registry last updated
Mar 1, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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