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Completed

NCT Number: NCT02109705

Porphyromonas Gingivalis and Alzheimer's Disease

With this study the investigators would like to analyze the the role of periodontal disease and especially the role of Porphyromonas gingivalis in initiation and progression of Alzheimer's Disease.

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Key information

Conditions

Alzheimer's Disease Alzheimer Disease Brain Diseases Central Nervous System Diseases Dementia Mental Disorders Mouth Diseases Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Periodontal Diseases Periodontitis Stomatognathic Diseases Tauopathies

Age range

40 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Periodontology

Münster, 48143, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age 40-70
  • caucasian origin
  • dementia (Alzheimer's or other dementia)
  • cognitive healthy (need for spinal anesthesia)

Exclusion criteria

  • use of antibiotics within las 6 months
  • pregnancy
  • another illness explaining the symptoms in a better way
  • smoking (>10 cigarettes)
  • patients who have a legal custodian

Treatment and study plan

Primary outcomes

  1. Cmax Antibody Levels against Gingipains

    Time frame: Baseline

    laboratory analysis

Secondary outcomes

  1. Cmax Beta-Amyloid

    Time frame: Baseline

    laboratory analysis

Other outcomes

  1. Cmax: Periodontal pathogens

    Time frame: Baseline

    laboratory analysis

  2. U enzyme activities

    Time frame: Baseline

    laboratory analysis

  3. Cmax: inflammatory cytokines

    Time frame: Baseline

    laboratory analysis

Sponsors and collaborators

Lead sponsor

University Hospital Muenster

Other

Collaborators

  • University of Bern

Registry information

Official study title

Porphyromonas Gingivalis - a Responsible Pathogen in Alzheimer's Disease?

Acronym: PGNEURO

Important dates

Study start
2014
Primary completion
2021
Study completion
2021
First posted
Apr 10, 2014
Registry last updated
May 31, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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