Polyuria Associated With Dexmedetomidine in Operating Room

This is a prospective, observational study designed to determine the incidence of polyuria, defined as urine output greater than 150 ml/h or 3 ml/kg/h, associated with the administration of dexmedetomidine during the intraoperative period.

The investigators will prospectively and consecutively study all patients scheduled for high complexity surgery under general anesthesia for a period of 4 months.

The diuretic rate will be quantified in ml/hour. A urine sample will be taken two hours after the start of surgery to assess sodium and urinary density, and an arterial blood sample will be taken to determine serum sodium.

Hydration will be recorded in milliliters per hour, detailing the type of solution used.

All data obtained will be captured in a RedCap data collection form.

Inclusion criteria

• Age > 18 years old
• Scheduled surgery
• Dexmedetomidine in boluses and/or continuous infusion during intra-operative period
• Patients who require arterial line and urinary catheter

Exclusion criteria

• Chronic renal disease.
• eGFR < 60 ml/min/1.73m2 for more than 3 months of evolution.
• Emergency or unscheduled surgeries.
• Central nervous system disease at the sellar or suprasellar level.
• Patients receiving diuretics.
• Liver cirrhosis.
• Adrenal gland disease.