Polyphenols and Risk of Dementia

This project aims to leverage existing data from a large observational prospective study on dementia, the Three-City study, to investigate the relationship between intakes of polyphenols and the risk to develop dementia in the 12 years following dietary assessment.

Completed

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Key information

Conditions

Diet, Polyphenols, Flavonoids, Stilbenes, Aged, Dementia, Alzheimer's Disease, Epidemiology Alzheimer Disease Brain Diseases Central Nervous System Diseases Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Tauopathies

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

The study sample includes 1,329 subjects followed for up to 12 years fro dementia after dietary assessment. The aim is to identify a pattern of polyphenol intake (based on 26 flavonoid and non-flavonoid polyphenol subclasses ascertained using a 24-hour dietary recall) associated with the risk of dementia and AD over 12 years in the 3C Bordeaux cohort.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

65 years or more, live in Bordeaux area (France)

Exclusion criteria

with dementia at the time of dietary assessment in year 2001-2002

Treatment and study plan

observational study (no intervention)

Other

Statistical association between adherence to a pattern of polyphenol intake and the risk to develop dementia and Alzheimer's disease over 12 years

Other names: pattern of polyphenol intake

Primary outcomes

incidence of dementia

Time frame: 12 years

incident cases of dementia diagnosed by the expert committee of neurologists at follow-up visits

Secondary outcomes

incidence of Alzheimer's disease

Time frame: 12 years

dementia with probable or possible Alzheimer etiology

Sponsors and collaborators

Lead sponsor

Jean-François Dartigues

Other

Registry information

Official study title

Pattern of Polyphenol Intake and the Long-term Risk of Dementia in Older Persons

Important dates

Study start: 1999
Primary completion: 2015
Study completion: 2015
First posted: Sep 18, 2017
Registry last updated: Sep 18, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed