Polyphenols and Insulin Resistance

Inclusion criteria

• Absence of anti HIV or anti hepatitis C antibodies and of HBS antigen.
• Acceptable biological assessment of the hepatic and renal functions (γGT, ALAT, ASAT < 3 times the normal value and serum creatinine <150 micromol/l).
• Age between 30 and 55 years.
• Fasting plasma glucose <110 mg/dl and absence of any anti-diabetic treatment
• No regular physical activity (Voorips index < 9)
• Absence of any drug treatment in progress and during the last 2 months
• Subjects with at least one 1st degree relative with T2D and with a body mass index between 25 and 35 kg/m² and a waist measurement >94 cm for males, and >80 cm for females.
• Normal ionogram (sodium 135 - 145 mmol/l, potassium 3,5 - 4,5 mmol/l).
• Normal ferritin level (75 - 300 ng/ml)
• hs-CRP <8 mg/l.
• Absence of arterial hypertension (systolic pressure <140 mmHg and diastolic pressure <90 mmHg).
• Non smoker or former smoker (quit smoking >1 year).
• Alcohol consumption <30 g/day.

Exclusion criteria

• Hyperthermia (T°>38°c)
• Subject deprived of freedom by a court or administrative order
• Major protected by the law
• Subject who is in a period of relative exclusion due to his/her participation to another protocol or for whom the annual maximum amount of allowances of 3 811.23 € is reached.
• Subject who has been treated with anti-coagulants, anti-inflammatory drugs, b-blockers or insulin during the last month.
• Subject who cannot be subjected to muscle biopsy.
• Allergy to the anaesthetic
• Woman in age to procreate and not taking any oral or intra-uterine contraception