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NCT Number: NCT07388394

Polypharmacy on Healthy Aging in People Living With HIV Over the Age of 75

Since the advent of antiretroviral treatments, the life expectancy of people living with HIV (PLHIV) has increased significantly. In France, more than 30% of PLHIV are now over 50 years old. This population is exposed to high multimorbidity, leading to frequent polypharmacy, defined as the regular use of at least five medications. Polypharmacy also has a qualitative dimension, including potentially inappropriate prescriptions. It increases the risk of adverse effects and drug interactions and impairs quality of life. A coordinated geriatric approach is therefore essential to optimize care. Healthy aging, promoted by the WHO, aims to improve the lives of older people. In this context, a study will be conducted at the Nice University Hospital among PLHIV aged 75 and over. It will collect quantitative data, the results of which will enable us to consider, if necessary, adapting the care pathways of these patients whose needs are complex.

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Key information

Conditions

Virus-HIV Acquired Immunodeficiency Syndrome Blood-Borne Infections Communicable Diseases Genital Diseases HIV Infections Immune System Diseases Immunologic Deficiency Syndromes Infections Lentivirus Infections RNA Virus Infections Retroviridae Infections Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Slow Virus Diseases Urogenital Diseases Virus Diseases

Age range

75 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • HIV-positive
  • Aged 75 or over
  • Affiliated with the social security system
  • Having expressed no objection to participating in the study

Exclusion criteria

  • Refusal to participate
  • Known severe cognitive impairment preventing the interview from being conducted
  • Patient under guardianship or conservatorship

Treatment and study plan

interview with advanced practice nurse

Other

45 to 60 minutes of interview

Primary outcomes

  1. Describe polypharmacy among people living with HIV aged 75 and older.

    Time frame: 15 months

    The average number of medications taken

Secondary outcomes

  1. Assess the most common comorbidities associated with polypharmacy in the population of PLHIV aged 75

    Time frame: 15 months

    Number et type of comorbidities

  2. Assess whether people taking multiple medications have a lower treatment adherence score than those taking fewer medications.

    Time frame: 15 months

    Score obtained on the Morisky MMAS-8 questionnaire

  3. Assess the level of functional independence in this age group and link it to the existence of polypharmacy.

    Time frame: 15 months

    Lawton and Brody IADL scale

Study contacts

Contact information is provided by the study sponsor or research team.

Irit TOUITOU

CONTACT

[email protected]

Lysandre BLANCKEMAN

CONTACT

[email protected]

04 92 03 54 67

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Official study title

Describe and Evaluate the Impact of Polypharmacy on Healthy Aging in People Living With HIV Over the Age of 75 Who Are Being Treated at Nice University Hospital.

Acronym: POLYVIH

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Feb 5, 2026
Registry last updated
Jun 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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