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Completed

NCT Number: NCT03133182

Polypharmacy and Outcomes After Elective Noncardiac Surgery

This study investigates the association of preoperative polypharmacy with outcomes and healthcare resource utilization in a population-based sample of older patients enrolled in a universal pharmacare program

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Key information

Conditions

Polypharmacy Epidemiology Morality Surgical Procedure, Operative

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Multilevel multivariable regression analysis will be used to investigate the adjusted association between preoperative polypharmacy and postoperative outcomes and healthcare resource utilization. Sensitivity analyses will be used to evaluate the robustness of the primary analysis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Intermediate to high risk elective non-cardiac surgery
  • Age >=66 on day of surgery

Exclusion criteria

-

Treatment and study plan

Polypharmacy

Drug

Patients who are taking >=5 unique prescription drugs in the 3 months prior to surgery

Primary outcomes

  1. Mortality

    Time frame: from day of surgery up to 90 days after surgery

    death from any cause

Secondary outcomes

  1. Complications

    Time frame: From day of surgery to day of hospital discharge, up to 365 days after surgery

    Patient with a complication based on clusters of ICD-10 Type 2 codes collected in the hospital record

  2. Length of Stay

    Time frame: date of surgery to date of hospital discharge, or 365 days after surgery, whichever comes first

    Number of days in hospital after surgery

  3. Costs of Care

    Time frame: date of surgery up to 90 days after surgery

    Costs related to medical care paid for by the provincial health insurance system

  4. Institutional Discharge

    Time frame: date of surgery to date of hospital discharge, or 365 days after surgery, whichever comes first

    A discharge location at the end of the surgical episode of care that is not back to the patient's original residence (specifically respite or long term care)

  5. Hospital Readmission

    Time frame: From the date of hospital discharge to 30 days after the date of discharge

    Acute hospital readmission after discharge from index hospitalization

Sponsors and collaborators

Lead sponsor

Ottawa Hospital Research Institute

Other

Registry information

Official study title

Association of Polypharmacy With Outcomes After Elective Noncardiac Surgery: a Population-based Cohort Study

Important dates

Study start
2002
Primary completion
2014
Study completion
2014
First posted
Apr 28, 2017
Registry last updated
Jan 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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