Polymorphism of beta2-adrenoceptor and Regular Use of Formoterol in Asthma

Polymorphism at codon 16 of the beta2-adrenoceptor (beta2-AR) affects the responsiveness to salmeterol in asthmatics. Data concerning formoterol are more controversial in literature. The aim of this study was to verify whether homozygote for arginine-16 (ArgArg16) and homozygote for glycine-16 (GlyGly16) genotypes differently influence the long-term responsiveness to formoterol.

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Key information

Conditions

Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Catholic University, Pneumology Unit

Rome, 00168, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Mild to moderate asthma
Stable clinical conditions

Exclusion criteria

Smokers
Current therapy with oral steroids
Exacerbations within the past 3 months

Treatment and study plan

Formoterol

Drug

Primary outcomes

Peak Expiratory Flow (PEF) variability

Time frame: PEF has been monitorized during the 4-week treatment period

Secondary outcomes

Forced Expiratory Volume in 1 sec (FEV1) slope of the dose-response curve to salbutamol

Time frame: At the end of the 4-week treatment period

Sponsors and collaborators

Lead sponsor

Catholic University, Italy

Other

Registry information

Official study title

Polymorphism of beta2-adrenoceptor and Regular Use of Formoterol in Asthma: Preliminary Results

Important dates

Study start: 2005
Primary completion: 2010
First posted: Feb 8, 2013
Registry last updated: Feb 8, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed